Contents
Vol 5, Issue 197
Contents
Focus
- Cup of Joe: A Brain Development “No”?
Treating pregnant mice with adenosine receptor antagonists including caffeine results in delayed migration of cortical GABA neurons and altered brain development in mouse offspring (Silva et al.).
- Genomics Traces Carcinogen Fingerprints
Genome-wide sequencing highlights the distinctive pattern of mutations caused by a plant that contains a potent carcinogen.
Research Articles
- Genome-Wide Mutational Signatures of Aristolochic Acid and Its Application as a Screening Tool
Genome-wide mutational signatures of the group 1 carcinogen aristolochic acid are observed in urothelial cancers and liver cancers from Asia.
- Mutational Signature of Aristolochic Acid Exposure as Revealed by Whole-Exome Sequencing
The mutational signature of aristolochic acid exemplifies how genome-wide sequencing can be used to identify environmental exposures leading to cancer.
- Identification of a Titin-Derived HLA-A1–Presented Peptide as a Cross-Reactive Target for Engineered MAGE A3–Directed T Cells
T cells engineered to express affinity-enhanced TCRs directed to a MAGE A3 peptide cross-react with a similar, but unrelated, self-peptide.
- Adenosine Receptor Antagonists Including Caffeine Alter Fetal Brain Development in Mice
Exposure to adenosine receptor antagonists in utero affects fetal brain development in mice.
Editors' Choice
- More and Better Bone Formation for the Elderly
Repair of critical-size bone defects in aged animals is improved when bone grafts are incubated with stem-cell factor Wnt3a before implantation.
- One Drop, Many Possibilities
Droplet-based microfluidics can be used for high-throughput single-cell sorting and gene expression analysis.
- REG1B: A Marker of Childhood Stunting
Stool regenerating gene 1b (REG1B) may serve as a noninvasive biomarker of future childhood stunting.
- Drugging the Undruggable
Potentially therapeutic small-molecule inhibitors of Aurora-A induce proteasomal degradation of N-Myc in childhood neuroblastoma.
- Pumping Iron Alters DNA Methylation
After a 6-month exercise regimen, sedentary men show DNA methylation changes in adipose tissue.
Podcast
- Science Translational Medicine Podcast: 7 August 2013
In this podcast, Bin Tean Teh explains the carcinogenic effects of aristolochic acid, an herbal compound used in traditional Chinese medicine.