Contents

07 August 2013
Vol 5, Issue 197

  • Contents

    • Focus

      • Cup of Joe: A Brain Development “No”?

        By Zeeba D. Kabir, Deirdre M. McCarthy, Pradeep G. Bhide, Barry E. Kosofsky

        Science Translational Medicine : 197fs30

        Treating pregnant mice with adenosine receptor antagonists including caffeine results in delayed migration of cortical GABA neurons and altered brain development in mouse offspring (Silva et al.).

    • Research Articles

      • Genome-Wide Mutational Signatures of Aristolochic Acid and Its Application as a Screening Tool

        By Song Ling Poon, See-Tong Pang, John R. McPherson, Willie Yu, Kie Kyon Huang, Peiyong Guan, Wen-Hui Weng, Ee Yan Siew, Yujing Liu, Hong Lee Heng, Soo Ching Chong, Anna Gan, Su Ting Tay, Weng Khong Lim, Ioana Cutcutache, Dachuan Huang, Lian Dee Ler, Maarja-Liisa Nairismägi, Ming Hui Lee, Ying-Hsu Chang, Kai-Jie Yu, Waraporn Chan-on, Bin-Kui Li, Yun-Fei Yuan, Chao-Nan Qian, Kwai-Fong Ng, Ching-Fang Wu, Cheng-Lung Hsu, Ralph M. Bunte, Michael R. Stratton, P. Andrew Futreal, Wing-Kin Sung, Cheng-Keng Chuang, Choon Kiat Ong, Steven G. Rozen, Patrick Tan, Bin Tean Teh

        Science Translational Medicine : 197ra101

        Genome-wide mutational signatures of the group 1 carcinogen aristolochic acid are observed in urothelial cancers and liver cancers from Asia.

      • Mutational Signature of Aristolochic Acid Exposure as Revealed by Whole-Exome Sequencing

        By Margaret L. Hoang, Chung-Hsin Chen, Viktoriya S. Sidorenko, Jian He, Kathleen G. Dickman, Byeong Hwa Yun, Masaaki Moriya, Noushin Niknafs, Christopher Douville, Rachel Karchin, Robert J. Turesky, Yeong-Shiau Pu, Bert Vogelstein, Nickolas Papadopoulos, Arthur P. Grollman, Kenneth W. Kinzler, Thomas A. Rosenquist

        Science Translational Medicine : 197ra102

        The mutational signature of aristolochic acid exemplifies how genome-wide sequencing can be used to identify environmental exposures leading to cancer.

      • Identification of a Titin-Derived HLA-A1–Presented Peptide as a Cross-Reactive Target for Engineered MAGE A3–Directed T Cells

        By Brian J. Cameron, Andrew B. Gerry, Joseph Dukes, Jane V. Harper, Vivekanandan Kannan, Frayne C. Bianchi, Francis Grand, Joanna E. Brewer, Minnal Gupta, Gabriela Plesa, Giovanna Bossi, Annelise Vuidepot, Alex S. Powlesland, Alison Legg, Katherine J. Adams, Alan D. Bennett, Nicholas J. Pumphrey, Daniel D. Williams, Gwendolyn Binder-Scholl, Irina Kulikovskaya, Bruce L. Levine, James L. Riley, Angel Varela-Rohena, Edward A. Stadtmauer, Aaron P. Rapoport, Gerald P. Linette, Carl H. June, Namir J. Hassan, Michael Kalos, Bent K. Jakobsen

        Science Translational Medicine : 197ra103

        T cells engineered to express affinity-enhanced TCRs directed to a MAGE A3 peptide cross-react with a similar, but unrelated, self-peptide.

      • Adenosine Receptor Antagonists Including Caffeine Alter Fetal Brain Development in Mice

        By Carla G. Silva, Christine Métin, Walid Fazeli, Nuno J. Machado, Sanja Darmopil, Pierre-Serge Launay, Antoine Ghestem, Marie-Pascale Nesa, Emilie Bassot, Eszter Szabó, Younis Baqi, Christa E. Müller, Angelo R. Tomé, Anton Ivanov, Dirk Isbrandt, Yuri Zilberter, Rodrigo A. Cunha, Monique Esclapez, Christophe Bernard

        Science Translational Medicine : 197ra104

        Exposure to adenosine receptor antagonists in utero affects fetal brain development in mice.

    • Editors' Choice

      • More and Better Bone Formation for the Elderly

        By Mercedes Balcells

        Science Translational Medicine : 197ec128

        Repair of critical-size bone defects in aged animals is improved when bone grafts are incubated with stem-cell factor Wnt3a before implantation.

      • One Drop, Many Possibilities

        By Edward Kai-Hua Chow

        Science Translational Medicine : 197ec129

        Droplet-based microfluidics can be used for high-throughput single-cell sorting and gene expression analysis.

      • REG1B: A Marker of Childhood Stunting

        By MUSTAFA MAHFUZ

        Science Translational Medicine : 197ec130

        Stool regenerating gene 1b (REG1B) may serve as a noninvasive biomarker of future childhood stunting.

      • Drugging the Undruggable

        By Goutham Narla

        Science Translational Medicine : 197ec131

        Potentially therapeutic small-molecule inhibitors of Aurora-A induce proteasomal degradation of N-Myc in childhood neuroblastoma.

      • Pumping Iron Alters DNA Methylation

        By Benjamin M. Neale

        Science Translational Medicine : 197ec132

        After a 6-month exercise regimen, sedentary men show DNA methylation changes in adipose tissue.

    • Podcast

      • Science Translational Medicine Podcast: 7 August 2013

        By Bin Tean Teh, Yevgeniya Nusinovich

        Science Translational Medicine : 197pc5

        In this podcast, Bin Tean Teh explains the carcinogenic effects of aristolochic acid, an herbal compound used in traditional Chinese medicine.

More From Science Translational Medicine

About The Cover

Cover image expansion

ONLINE COVER A Not-So-Harmless Plant. Shown is a flower of Aristolochia baetica, one of the many species that make up the genus Aristolochia. Members of this genus are found in most parts of the world and have been used as herbal remedies in Asia for centuries. In recent years, aristolochic acid, a chemical compound found in these plants, was shown to cause kidney damage and urinary tract cancers. It has since been banned in several countries, but many people are still exposed to it through herbal mixtures or as an accidental contaminant. Now, Poon et al. and Hoang et al. have discovered that exposure to aristolochic acid leaves a tell-tale pattern of mutations in patients' DNA and may be responsible for more cancers than previously suspected. See also the accompanying Focus by Lee and Ladanyi and a related Podcast by Bin Tean Teh. [CREDIT: CARSTEN NIEHAUS/WIKIMEDIA COMMONS]