Research ArticleCancer

mTORC1 Inhibition Is Required for Sensitivity to PI3K p110α Inhibitors in PIK3CA-Mutant Breast Cancer

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Science Translational Medicine  31 Jul 2013:
Vol. 5, Issue 196, pp. 196ra99
DOI: 10.1126/scitranslmed.3005747

Article Information

vol. 5 no. 196 196ra99

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication January 22, 2013
  • Accepted for publication June 25, 2013
  • .

Author Information

  1. Moshe Elkabets1,2,*,
  2. Sadhna Vora2,*,
  3. Dejan Juric2,*,
  4. Natasha Morse1,
  5. Mari Mino-Kenudson3,
  6. Taru Muranen4,
  7. Jessica Tao2,
  8. Ana Bosch Campos1,
  9. Jordi Rodon5,
  10. Yasir H. Ibrahim5,
  11. Violeta Serra5,
  12. Vanessa Rodrik-Outmezguine6,
  13. Saswati Hazra7,
  14. Sharat Singh7,
  15. Phillip Kim7,
  16. Cornelia Quadt8,
  17. Manway Liu9,
  18. Alan Huang9,
  19. Neal Rosen6,
  20. Jeffrey A. Engelman2,
  21. Maurizio Scaltriti1, and
  22. José Baselga1,
  1. 1Human Oncology & Pathogenesis Program and Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 20, New York, NY 10065, USA.
  2. 2Massachusetts General Hospital Cancer Center, CNY 149, 13th Street, Charlestown, MA 02129, USA.
  3. 3Department of Pathology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA.
  4. 4Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA.
  5. 5Experimental Therapeutics Group, Vall d’Hebron Institute of Oncology, Pg Vall d’Hebron, 119-129, Barcelona 08035, Spain.
  6. 6Molecular Pharmacology and Chemistry Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  7. 7Prometheus Therapeutics & Diagnostics, 9410 Carroll Park Drive, San Diego, CA 92121, USA.
  8. 8Novartis Pharma AG, Forum 1, Novartis Campus, CH-4056 Basel, Switzerland.
  9. 9Oncology Translational Medicine, Novartis Institutes for BioMedical Research, Cambridge, MA 02139, USA.
  1. Corresponding author. E-mail: scaltrim{at}mskcc.org (M.S.); baselgaj{at}mskcc.org (J.B.)
  • * These authors contributed equally to this work.

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