Research ArticleCancer

TORC1 Suppression Predicts Responsiveness to RAF and MEK Inhibition in BRAF-Mutant Melanoma

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Science Translational Medicine  31 Jul 2013:
Vol. 5, Issue 196, pp. 196ra98
DOI: 10.1126/scitranslmed.3005753

Article Information

vol. 5 no. 196 196ra98

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication January 22, 2013
  • Accepted for publication June 19, 2013

Author Information

  1. Ryan B. Corcoran1,2,*,
  2. Stephen Michael Rothenberg1,2,*,
  3. Aaron N. Hata1,2,
  4. Anthony C. Faber1,
  5. Adriano Piris3,
  6. Rosalynn M. Nazarian3,
  7. Ronald D. Brown1,
  8. Jason T. Godfrey1,
  9. Daniel Winokur1,
  10. John Walsh1,
  11. Mari Mino-Kenudson3,
  12. Shyamala Maheswaran1,
  13. Jeffrey Settleman4,
  14. Jennifer A. Wargo1,5,
  15. Keith T. Flaherty1,2,
  16. Daniel A. Haber1,2,6, and
  17. Jeffrey A. Engelman1,2,
  1. 1Massachusetts General Hospital Cancer Center, Boston, MA 02129, USA.
  2. 2Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
  3. 3Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02115, USA.
  4. 4Genentech Inc., South San Francisco, CA 94080, USA.
  5. 5Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02115, USA.
  6. 6Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.
  1. Corresponding author. E-mail: jengelman{at}partners.org (J.A.E.); dhaber{at}partners.org (D.A.H.)
  • * These authors contributed equally to this work.

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