Contents
Vol 5, Issue 196
Contents
Editorial
- Assessing NIH’s Big Idea
Central leadership and creative collaborations will enhance the harvest of the U.S. Clinical and Translational Science Award network.
Commentary
- Breaking a Vicious Cycle
New tumor-biomarker diagnostics will emerge along with changes in regulation, development, reimbursement, and investment practices.
Research Articles
- TORC1 Suppression Predicts Responsiveness to RAF and MEK Inhibition in BRAF-Mutant Melanoma
Suppression of TORC1 activity after treatment with RAF or MEK inhibitors predicts drug sensitivity in BRAF-mutant melanoma and can be monitored in patients.
- mTORC1 Inhibition Is Required for Sensitivity to PI3K p110α Inhibitors in PIK3CA-Mutant Breast Cancer
Persistent mTORC1 signaling correlates with resistance to PI3K p110α inhibition in breast cancer, which can be overcome by inhibiting mTORC1.
- Transforming Growth Factor–β Signaling in T Cells Promotes Stabilization of Atherosclerotic Plaques Through an Interleukin-17–Dependent Pathway
Enhanced TGF-β signaling may promote plaque stability and prevent clinical manifestations of atherosclerosis.
Editors' Choice
- Linking an Obesity-Associated Gene Variant, Ghrelin, and the Brain
An obesity-associated gene variant may predispose people to obesity by affecting hunger, ghrelin levels, and neural responses to food images.
- The Bionic Cancer-Resistant Extracellular Matrix of the Naked Mole-Rat
Naked mole-rats resist cancer through a high-molecular-mass version of the extracellular matrix component hyaluronan.
- Bacterial Vibrations
Nanoscale movements of bacteria uncover their resistance to antibiotics.
- Ironing Out Parkinson’s Disease
Human genetics demonstrates that a higher concentration of serum iron protects against Parkinson’s disease.
