CaMKII Is Essential for the Proasthmatic Effects of Oxidation

Philip N. Sanders; Olha M. Koval; Omar A. Jaffer; Anand M. Prasad; Thomas R. Businga; Jason A. Scott; Patrick J. Hayden; Elizabeth D. Luczak; David D. Dickey; Chantal Allamargot; Alicia K. Olivier; David K. Meyerholz; Alfred J. Robison; Danny G. Winder; Timothy S. Blackwell; Ryszard Dworski; David Sammut; Brett A. Wagner; Garry R. Buettner; Robert M. Pope; Francis J. Miller; Megan E. Dibbern; Hans Michael Haitchi; Peter J. Mohler; Peter H. Howarth; Joseph Zabner; Joel N. Kline; Isabella M. Grumbach; Mark E. Anderson

doi:10.1126/scitranslmed.3006135

Research ArticleAsthma

CaMKII Is Essential for the Proasthmatic Effects of Oxidation

Philip N. Sanders¹,
Olha M. Koval¹,
Omar A. Jaffer¹,
Anand M. Prasad¹,
Thomas R. Businga¹,
Jason A. Scott¹,
Patrick J. Hayden²,
Elizabeth D. Luczak¹,
David D. Dickey¹,
Chantal Allamargot³,
Alicia K. Olivier⁴,
David K. Meyerholz⁴,
Alfred J. Robison⁵,
Danny G. Winder⁶,
Timothy S. Blackwell⁷,
Ryszard Dworski⁷,
David Sammut⁸,
Brett A. Wagner⁹,
Garry R. Buettner⁹,
Robert M. Pope¹⁰,
Francis J. Miller Jr.¹,¹¹,
Megan E. Dibbern¹,
Hans Michael Haitchi⁸,
Peter J. Mohler¹²,
Peter H. Howarth⁸,
Joseph Zabner¹,
Joel N. Kline¹,
Isabella M. Grumbach¹,¹¹,¹³,* and
Mark E. Anderson¹,¹¹,¹⁴,*

¹Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.
²MatTek Corporation, 200 Homer Avenue, Ashland, MA 01721, USA.
³Central Microscopy Research Facilities, University of Iowa, Iowa City, IA 52242, USA.
⁴Department of Pathology, Medical Laboratories, University of Iowa, Iowa City, IA 52242, USA.
⁵Department of Physiology, Michigan State University, East Lansing, MI 48824, USA.
⁶Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
⁷Department of Internal Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
⁸Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton and NIHR Respiratory Bioscience Research Unit, Southampton General Hospital, Southampton, Hants SO16 6YD, UK.
⁹Free Radical and Radiation Biology Program, Department of Radiation Oncology, University of Iowa, Iowa City, IA 52242, USA.
¹⁰Proteomics Facility, University of Iowa, Iowa City, IA 52242, USA.
¹¹University of Iowa Cardiovascular Research Center, Iowa City, IA 52242, USA.
¹²The Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA.
¹³Iowa City VA Healthcare System, Iowa City, IA 52246, USA.
¹⁴Department of Molecular Physiology and Biophysics, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.

↵*Corresponding author. E-mail: mark-e-anderson{at}uiowa.edu (M.E.A.); isabella-grumbach{at}uiowa.edu (I.M.G.)

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Science Translational Medicine 24 Jul 2013:
Vol. 5, Issue 195, pp. 195ra97
DOI: 10.1126/scitranslmed.3006135

Philip N. Sanders

1Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.

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Olha M. Koval

1Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.

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Omar A. Jaffer

1Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.

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Anand M. Prasad

1Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.

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Thomas R. Businga

1Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.

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Jason A. Scott

1Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.

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Patrick J. Hayden

2MatTek Corporation, 200 Homer Avenue, Ashland, MA 01721, USA.

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Elizabeth D. Luczak

1Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.

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David D. Dickey

1Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.

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Chantal Allamargot

3Central Microscopy Research Facilities, University of Iowa, Iowa City, IA 52242, USA.

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Alicia K. Olivier

4Department of Pathology, Medical Laboratories, University of Iowa, Iowa City, IA 52242, USA.

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David K. Meyerholz

4Department of Pathology, Medical Laboratories, University of Iowa, Iowa City, IA 52242, USA.

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Alfred J. Robison

5Department of Physiology, Michigan State University, East Lansing, MI 48824, USA.

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Danny G. Winder

6Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.

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Timothy S. Blackwell

7Department of Internal Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.

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Ryszard Dworski

7Department of Internal Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.

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David Sammut

8Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton and NIHR Respiratory Bioscience Research Unit, Southampton General Hospital, Southampton, Hants SO16 6YD, UK.

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Brett A. Wagner

9Free Radical and Radiation Biology Program, Department of Radiation Oncology, University of Iowa, Iowa City, IA 52242, USA.

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Garry R. Buettner

9Free Radical and Radiation Biology Program, Department of Radiation Oncology, University of Iowa, Iowa City, IA 52242, USA.

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Robert M. Pope

10Proteomics Facility, University of Iowa, Iowa City, IA 52242, USA.

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Francis J. Miller Jr.

1Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.

11University of Iowa Cardiovascular Research Center, Iowa City, IA 52242, USA.

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Megan E. Dibbern

1Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.

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Hans Michael Haitchi

8Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton and NIHR Respiratory Bioscience Research Unit, Southampton General Hospital, Southampton, Hants SO16 6YD, UK.

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Peter J. Mohler

12The Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA.

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Peter H. Howarth

8Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton and NIHR Respiratory Bioscience Research Unit, Southampton General Hospital, Southampton, Hants SO16 6YD, UK.

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Joseph Zabner

1Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.

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Joel N. Kline

1Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.

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Isabella M. Grumbach

1Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.

11University of Iowa Cardiovascular Research Center, Iowa City, IA 52242, USA.

13Iowa City VA Healthcare System, Iowa City, IA 52246, USA.

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For correspondence: mark-e-anderson@uiowa.edu isabella-grumbach@uiowa.edu

Mark E. Anderson

1Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.

11University of Iowa Cardiovascular Research Center, Iowa City, IA 52242, USA.

14Department of Molecular Physiology and Biophysics, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.

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For correspondence: mark-e-anderson@uiowa.edu isabella-grumbach@uiowa.edu

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CaMKII Is Essential for the Proasthmatic Effects of Oxidation

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