Contents
Vol 5, Issue 195
Contents
Focus
- When Killers Become Helpers
Interplay between natural killer and other cells in salivary glands influences pathogenesis of the autoimmune disease Sjögren's syndrome.
Perspective
- Preventing Newborn Infection with Maternal Immunization
Scientists met in Siena to conceive strategies for preventing often-fatal group B streptococcal disease in newborns.
Research Articles
- TGFβ Receptor Mutations Impose a Strong Predisposition for Human Allergic Disease
Patients with mutations in the receptors for TGFβ (Loeys-Dietz syndrome) exhibit an increased prevalence of allergic diseases.
- An Integrated Clinico-Metabolomic Model Improves Prediction of Death in Sepsis
A molecular signature, derived from integrated analysis of clinical data, the metabolome, and the proteome in prospective human studies, improved the prediction of death in patients with sepsis, potentially identifying a subset of patients who merit intensive treatment.
- NCR3/NKp30 Contributes to Pathogenesis in Primary Sjögren’s Syndrome
Genetic and functional analyses implicate NCR3/NKp30 in the pathogenesis of primary Sjögren’s syndrome.
- CaMKII Is Essential for the Proasthmatic Effects of Oxidation
Ca2+/calmodulin-dependent protein kinase (CaMKII) transduces oxidative stress into asthma-related diseases.
Editors' Choice
- Decreasing the CHANCE of Stroke
Combination treatment with clopidogrel and aspirin decreases the risk of stroke after a transient ischemic attack.
- An Inferiority Complex for Chemo
A drug combination without chemotherapy can cure leukemia patients with fewer toxic side effects.
- Transplanting Interneuron Precursors for Epilepsy Control
Transplantation of precursor cells for GABAergic interneurons suppresses seizures and behavioral deficits associated with epilepsy in mice.
- Red Hot Chili Peppers Rock Obesity Research
Exposure to cold or capsinoids found in chili peppers activates human brown fat, thus revealing a new target for obesity drugs.
Podcast
- Science Translational Medicine Podcast: 24 July 2013
Our most recent podcast is a conversation with Raymond J. Langley, who explains how a new molecular signature improves mortality prediction in patients with sepsis.
