24 July 2013
Vol 5, Issue 195
  • Contents

    • Focus

      • When Killers Become Helpers

        Interplay between natural killer and other cells in salivary glands influences pathogenesis of the autoimmune disease Sjögren's syndrome.

    • Perspective

    • Research Articles

      • TGFβ Receptor Mutations Impose a Strong Predisposition for Human Allergic Disease

        Patients with mutations in the receptors for TGFβ (Loeys-Dietz syndrome) exhibit an increased prevalence of allergic diseases.

      • An Integrated Clinico-Metabolomic Model Improves Prediction of Death in Sepsis

        A molecular signature, derived from integrated analysis of clinical data, the metabolome, and the proteome in prospective human studies, improved the prediction of death in patients with sepsis, potentially identifying a subset of patients who merit intensive treatment.

      • NCR3/NKp30 Contributes to Pathogenesis in Primary Sjögren’s Syndrome

        Genetic and functional analyses implicate NCR3/NKp30 in the pathogenesis of primary Sjögren’s syndrome.

      • CaMKII Is Essential for the Proasthmatic Effects of Oxidation

        Ca2+/calmodulin-dependent protein kinase (CaMKII) transduces oxidative stress into asthma-related diseases.

    • Editors' Choice

      • Decreasing the CHANCE of Stroke

        Combination treatment with clopidogrel and aspirin decreases the risk of stroke after a transient ischemic attack.

      • An Inferiority Complex for Chemo

        A drug combination without chemotherapy can cure leukemia patients with fewer toxic side effects.

      • Red Hot Chili Peppers Rock Obesity Research

        Exposure to cold or capsinoids found in chili peppers activates human brown fat, thus revealing a new target for obesity drugs.

    • Podcast

      • Science Translational Medicine Podcast: 24 July 2013

        Our most recent podcast is a conversation with Raymond J. Langley, who explains how a new molecular signature improves mortality prediction in patients with sepsis.

About The Cover

Cover image expansion

ONLINE COVER Bringing Allergy into Focus. Asthma and allergy, which occur when a person’s immune system attacks a normally harmless substance, are becoming increasingly prevalent in developed countries. In this issue of Science Translational Medicine, Frischmeyer-Guerrerio et al. report that patients with Loeys-Dietz syndrome, who have mutations in the receptors for transforming growth factor–β (TGFβ), are more likely to develop allergic diseases. These data suggest that altered TGFβ signaling could promote allergic disease and support testing for U.S. Food and Drug Administration–approved drugs that affect TGFβ for treating allergy. [CREDIT: JUAN MONINO/ISTOCKPHOTO]