Genomics in Clinical Practice: Lessons from the Front Lines

Howard J. Jacob; Kelly Abrams; David P. Bick; Kent Brodie; David P. Dimmock; Michael Farrell; Jennifer Geurts; Jeremy Harris; Daniel Helbling; Barbara J. Joers; Robert Kliegman; George Kowalski; Jozef Lazar; David A. Margolis; Paula North; Jill Northup; Altheia Roquemore-Goins; Gunter Scharer; Mary Shimoyama; Kimberly Strong; Bradley Taylor; Shirng-Wern Tsaih; Michael R. Tschannen; Regan L. Veith; Jaime Wendt-Andrae; Brandon Wilk; Elizabeth A. Worthey

doi:10.1126/scitranslmed.3006468

CommentaryGenomics

Genomics in Clinical Practice: Lessons from the Front Lines

Howard J. Jacob¹,⁵,⁶,^*,
Kelly Abrams¹²,
David P. Bick¹,⁵,¹⁰,
Kent Brodie¹,
David P. Dimmock¹,⁵,¹⁰,
Michael Farrell³,
Jennifer Geurts¹,⁷,
Jeremy Harris¹,⁵,
Daniel Helbling¹,⁵,
Barbara J. Joers¹²,
Robert Kliegman⁵,
George Kowalski¹,
Jozef Lazar¹,²,
David A. Margolis⁵,
Paula North⁴,⁹,¹¹,
Jill Northup¹,
Altheia Roquemore-Goins¹¹,
Gunter Scharer¹,⁵,¹⁰,
Mary Shimoyama¹,⁷,
Kimberly Strong¹,⁸,
Bradley Taylor¹,
Shirng-Wern Tsaih¹,
Michael R. Tschannen¹,
Regan L. Veith¹,¹⁰,
Jaime Wendt-Andrae¹,
Brandon Wilk¹,⁵ and
Elizabeth A. Worthey¹,⁵,⁹

¹Human and Molecular Genetic Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA.
²Department of Dermatology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA.
³Department of Medicine, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA.
⁴Department of Pathology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA.
⁵Department of Pediatrics, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA.
⁶Department of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA.
⁷Department of Surgery, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA.
⁸The Institute of Health and Society, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA.
⁹Children’s Research Institute, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA.
¹⁰Genomics Medicine Clinic, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA.
¹¹Clinical Laboratory, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA.
¹²Operations, Children’s Hospital of Wisconsin, 9000 W. Wisconsin Avenue, Milwaukee, WI 53226, USA.

↵*Corresponding author. E-mail: jacob{at}mcw.edu

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Science Translational Medicine 17 Jul 2013:
Vol. 5, Issue 194, pp. 194cm5
DOI: 10.1126/scitranslmed.3006468

Howard J. Jacob

1Human and Molecular Genetic Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA.

5Department of Pediatrics, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA.

6Department of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA.

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For correspondence: jacob@mcw.edu

Kelly Abrams

12Operations, Children’s Hospital of Wisconsin, 9000 W. Wisconsin Avenue, Milwaukee, WI 53226, USA.

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David P. Bick

1Human and Molecular Genetic Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA.

5Department of Pediatrics, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA.

10Genomics Medicine Clinic, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA.

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Kent Brodie

1Human and Molecular Genetic Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA.

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David P. Dimmock

1Human and Molecular Genetic Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA.

5Department of Pediatrics, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA.

10Genomics Medicine Clinic, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA.

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Michael Farrell

3Department of Medicine, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA.

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Jennifer Geurts

1Human and Molecular Genetic Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA.

7Department of Surgery, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA.

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Jeremy Harris

1Human and Molecular Genetic Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA.

5Department of Pediatrics, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA.

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Daniel Helbling

1Human and Molecular Genetic Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA.

5Department of Pediatrics, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA.

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Barbara J. Joers

12Operations, Children’s Hospital of Wisconsin, 9000 W. Wisconsin Avenue, Milwaukee, WI 53226, USA.

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Robert Kliegman

5Department of Pediatrics, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA.

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George Kowalski

1Human and Molecular Genetic Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA.

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Jozef Lazar

1Human and Molecular Genetic Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA.

2Department of Dermatology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA.

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David A. Margolis

5Department of Pediatrics, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA.

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Paula North

4Department of Pathology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA.

9Children’s Research Institute, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA.

11Clinical Laboratory, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA.

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Jill Northup

1Human and Molecular Genetic Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA.

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Altheia Roquemore-Goins

11Clinical Laboratory, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA.

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Gunter Scharer

1Human and Molecular Genetic Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA.

5Department of Pediatrics, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA.

10Genomics Medicine Clinic, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA.

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Mary Shimoyama

1Human and Molecular Genetic Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA.

7Department of Surgery, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA.

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Kimberly Strong

1Human and Molecular Genetic Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA.

8The Institute of Health and Society, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA.

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Bradley Taylor

1Human and Molecular Genetic Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA.

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Shirng-Wern Tsaih

1Human and Molecular Genetic Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA.

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Michael R. Tschannen

1Human and Molecular Genetic Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA.

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Regan L. Veith

1Human and Molecular Genetic Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA.

10Genomics Medicine Clinic, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA.

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Jaime Wendt-Andrae

1Human and Molecular Genetic Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA.

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Brandon Wilk

1Human and Molecular Genetic Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA.

5Department of Pediatrics, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA.

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Elizabeth A. Worthey

1Human and Molecular Genetic Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA.

5Department of Pediatrics, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA.

9Children’s Research Institute, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA.

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