Dysbiosis of the Gut Microbiota Is Associated with HIV Disease Progression and Tryptophan Catabolism

Ivan Vujkovic-Cvijin; Richard M. Dunham; Shoko Iwai; Michael C. Maher; Rebecca G. Albright; Mara J. Broadhurst; Ryan D. Hernandez; Michael M. Lederman; Yong Huang; Ma Somsouk; Steven G. Deeks; Peter W. Hunt; Susan V. Lynch; Joseph M. McCune

doi:10.1126/scitranslmed.3006438

Research ArticleHIV

Dysbiosis of the Gut Microbiota Is Associated with HIV Disease Progression and Tryptophan Catabolism

Ivan Vujkovic-Cvijin¹,²,*,
Richard M. Dunham¹,*,
Shoko Iwai³,
Michael C. Maher⁴,
Rebecca G. Albright¹,
Mara J. Broadhurst¹,
Ryan D. Hernandez⁴,
Michael M. Lederman⁵,
Yong Huang⁶,
Ma Somsouk¹,³,
Steven G. Deeks⁷,
Peter W. Hunt⁷,
Susan V. Lynch³,*,† and
Joseph M. McCune¹,*,†

¹Division of Experimental Medicine, Department of Medicine, University of California, San Francisco (UCSF), San Francisco, CA 94110, USA.
²Biomedical Sciences Graduate Program, UCSF, San Francisco, CA 94143, USA.
³Division of Gastroenterology, Department of Medicine, UCSF, San Francisco, CA 94143, USA.
⁴Department of Epidemiology and Biostatistics, UCSF, San Francisco, CA 94107, USA.
⁵Division of Infectious Diseases, Department of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.
⁶Department of Bioengineering and Therapeutic Sciences, UCSF, San Francisco, CA 94143, USA.
⁷Positive Health Program, Department of Medicine, UCSF, San Francisco, CA 94110, USA.

↵†Corresponding author. E-mail: susan.lynch{at}ucsf.edu (S.V.L.); mike.mccune{at}ucsf.edu (J.M.M.)

↵* These authors contributed equally to this work.

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Science Translational Medicine 10 Jul 2013:
Vol. 5, Issue 193, pp. 193ra91
DOI: 10.1126/scitranslmed.3006438

Ivan Vujkovic-Cvijin

1Division of Experimental Medicine, Department of Medicine, University of California, San Francisco (UCSF), San Francisco, CA 94110, USA.

2Biomedical Sciences Graduate Program, UCSF, San Francisco, CA 94143, USA.

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Richard M. Dunham

1Division of Experimental Medicine, Department of Medicine, University of California, San Francisco (UCSF), San Francisco, CA 94110, USA.

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Shoko Iwai

3Division of Gastroenterology, Department of Medicine, UCSF, San Francisco, CA 94143, USA.

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Michael C. Maher

4Department of Epidemiology and Biostatistics, UCSF, San Francisco, CA 94107, USA.

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Rebecca G. Albright

1Division of Experimental Medicine, Department of Medicine, University of California, San Francisco (UCSF), San Francisco, CA 94110, USA.

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Mara J. Broadhurst

1Division of Experimental Medicine, Department of Medicine, University of California, San Francisco (UCSF), San Francisco, CA 94110, USA.

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Ryan D. Hernandez

4Department of Epidemiology and Biostatistics, UCSF, San Francisco, CA 94107, USA.

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Michael M. Lederman

5Division of Infectious Diseases, Department of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.

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Yong Huang

6Department of Bioengineering and Therapeutic Sciences, UCSF, San Francisco, CA 94143, USA.

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Ma Somsouk

1Division of Experimental Medicine, Department of Medicine, University of California, San Francisco (UCSF), San Francisco, CA 94110, USA.

3Division of Gastroenterology, Department of Medicine, UCSF, San Francisco, CA 94143, USA.

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Steven G. Deeks

7Positive Health Program, Department of Medicine, UCSF, San Francisco, CA 94110, USA.

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Peter W. Hunt

7Positive Health Program, Department of Medicine, UCSF, San Francisco, CA 94110, USA.

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Susan V. Lynch

3Division of Gastroenterology, Department of Medicine, UCSF, San Francisco, CA 94143, USA.

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For correspondence: susan.lynch@ucsf.edu mike.mccune@ucsf.edu

Joseph M. McCune

1Division of Experimental Medicine, Department of Medicine, University of California, San Francisco (UCSF), San Francisco, CA 94110, USA.

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For correspondence: susan.lynch@ucsf.edu mike.mccune@ucsf.edu

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Dysbiosis of the Gut Microbiota Is Associated with HIV Disease Progression and Tryptophan Catabolism

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