Contents
Vol 5, Issue 193
Contents
Focus
- Molecular Clues Assist in the Cancer Clinic
The winner of the 2013 AAAS Martin and Rose Wachtel Cancer Research Award navigates a journey from the prostate cancer genome to the clinic.
- Deconstructing Vitamin D Deficiency
Vitamin D deficiency causes cracking and aging of bone tissue.
Research Articles
- Vitamin D Deficiency Induces Early Signs of Aging in Human Bone, Increasing the Risk of Fracture
In addition to decreasing bone mass, vitamin D deficiency causes early aging of the remaining mineralized bone and leads to severe losses in fracture resistance.
- Plasmacytoid Dendritic Cells, Interferon Signaling, and FcγR Contribute to Pathogenesis and Therapeutic Response in Childhood Immune Thrombocytopenia
Targeting plasmacytoid dendritic cells or blockade of interferon response may benefit patients with an autoimmune disease against platelets.
- Overexpression of Vascular Endothelial Growth Factor in the Germinal Matrix Induces Neurovascular Proteases and Intraventricular Hemorrhage
A transgenic mouse model implicates specific neurovascular proteases in the pathogenesis of intracranial hemorrhage in preterm infants.
- Dysbiosis of the Gut Microbiota Is Associated with HIV Disease Progression and Tryptophan Catabolism
Gut-resident microbial populations may influence intestinal homeostasis during HIV disease.
Editors' Choice
- Bioprinting: Beyond the Natural Order of Creation
Computer modeling and three-dimensional bioprinting of composite materials with complex patterns create tunable biomaterials with superior mechanical properties.
- Fish Oil Cools the Inflammasome
Omega-3 fatty acids directly inhibit the NLRP3 inflammasome in vitro and decrease tissue inflammation and insulin resistance in mice.
- Mental Break(down) in the Nucleus
An inability to repair double-strand breaks in neuronal DNA may contribute to Alzheimer’s disease in a mouse model.
- Twinkle, Twinkle, Little Plaque
At high resolution, atherosclerotic plaques in coronary arteries show their microcalcifications.
Erratum
