eLetters is an online forum for ongoing peer review. Submission of eLetters are open to all. Please read our Terms of Service before submitting your own eLetter.
Research ArticleImmunology
TCR-Ligand koff Rate Correlates with the Protective Capacity of Antigen-Specific CD8+ T Cells for Adoptive Transfer
- Magdalena Nauerth1,*,
- Bianca Weißbrich1,*,
- Robert Knall1,*,
- Tobias Franz1,
- Georg Dössinger1,
- Jeannette Bet1,2,
- Paulina J. Paszkiewicz1,2,
- Lukas Pfeifer1,
- Mario Bunse3,4,
- Wolfgang Uckert3,4,
- Rafaela Holtappels5,
- Dorothea Gillert-Marien5,
- Michael Neuenhahn1,6,7,
- Angela Krackhardt6,8,
- Matthias J. Reddehase5,9,
- Stanley R. Riddell2,10,11 and
- Dirk H. Busch1,2,6,7,†
- 1Institute for Medical Microbiology, Immunology and Hygiene, Technische Universität München, 81675 Munich, Germany.
- 2Focus Group “Clinical Cell Processing and Purification,” Institute for Advanced Study, Technische Universität München, 81675 Munich, Germany.
- 3Max Delbrück Center for Molecular Medicine, 13125 Berlin, Germany.
- 4Humboldt-Universität Berlin, 10099 Berlin, Germany.
- 5Institute for Virology and Research Center for Immunology (FZI), University Medical Center of the Johannes Gutenberg-University, 55131 Mainz, Germany.
- 6Clinical Cooperation Groups “Antigen-specific Immunotherapy” and “Immune Monitoring,” Helmholtz Center Munich (85764 Neuherberg) and Technische Universität München, 81675 Munich, Germany.
- 7DZIF–National Centre for Infection Research, 81675 Munich, Germany.
- 8Medical Department III, Hematology and Oncology, Technische Universität München, 81675 Munich, Germany.
- 9Helmholtz Virtual Institute on Viral Strategies of Immune Evasion (VISTRIE), Helmholtz Centre for Infection Research, 38124 Braunschweig, Germany.
- 10Program in Immunology, Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
- 11Department of Medicine, University of Washington, Seattle, WA 98104, USA.
- ↵†Corresponding author. E-mail: dirk.busch{at}mikrobio.med.tum.de
-
↵* These authors contributed equally to this work.
See allHide authors and affiliations
Science Translational Medicine 03 Jul 2013:
Vol. 5, Issue 192, pp. 192ra87
DOI: 10.1126/scitranslmed.3005958
Vol. 5, Issue 192, pp. 192ra87
DOI: 10.1126/scitranslmed.3005958
Magdalena Nauerth
1Institute for Medical Microbiology, Immunology and Hygiene, Technische Universität München, 81675 Munich, Germany.
Bianca Weißbrich
1Institute for Medical Microbiology, Immunology and Hygiene, Technische Universität München, 81675 Munich, Germany.
Robert Knall
1Institute for Medical Microbiology, Immunology and Hygiene, Technische Universität München, 81675 Munich, Germany.
Tobias Franz
1Institute for Medical Microbiology, Immunology and Hygiene, Technische Universität München, 81675 Munich, Germany.
Georg Dössinger
1Institute for Medical Microbiology, Immunology and Hygiene, Technische Universität München, 81675 Munich, Germany.
Jeannette Bet
1Institute for Medical Microbiology, Immunology and Hygiene, Technische Universität München, 81675 Munich, Germany.
2Focus Group “Clinical Cell Processing and Purification,” Institute for Advanced Study, Technische Universität München, 81675 Munich, Germany.
Paulina J. Paszkiewicz
1Institute for Medical Microbiology, Immunology and Hygiene, Technische Universität München, 81675 Munich, Germany.
2Focus Group “Clinical Cell Processing and Purification,” Institute for Advanced Study, Technische Universität München, 81675 Munich, Germany.
Lukas Pfeifer
1Institute for Medical Microbiology, Immunology and Hygiene, Technische Universität München, 81675 Munich, Germany.
Mario Bunse
3Max Delbrück Center for Molecular Medicine, 13125 Berlin, Germany.
4Humboldt-Universität Berlin, 10099 Berlin, Germany.
Wolfgang Uckert
3Max Delbrück Center for Molecular Medicine, 13125 Berlin, Germany.
4Humboldt-Universität Berlin, 10099 Berlin, Germany.
Rafaela Holtappels
5Institute for Virology and Research Center for Immunology (FZI), University Medical Center of the Johannes Gutenberg-University, 55131 Mainz, Germany.
Dorothea Gillert-Marien
5Institute for Virology and Research Center for Immunology (FZI), University Medical Center of the Johannes Gutenberg-University, 55131 Mainz, Germany.
Michael Neuenhahn
1Institute for Medical Microbiology, Immunology and Hygiene, Technische Universität München, 81675 Munich, Germany.
6Clinical Cooperation Groups “Antigen-specific Immunotherapy” and “Immune Monitoring,” Helmholtz Center Munich (85764 Neuherberg) and Technische Universität München, 81675 Munich, Germany.
7DZIF–National Centre for Infection Research, 81675 Munich, Germany.
Angela Krackhardt
6Clinical Cooperation Groups “Antigen-specific Immunotherapy” and “Immune Monitoring,” Helmholtz Center Munich (85764 Neuherberg) and Technische Universität München, 81675 Munich, Germany.
8Medical Department III, Hematology and Oncology, Technische Universität München, 81675 Munich, Germany.
Matthias J. Reddehase
5Institute for Virology and Research Center for Immunology (FZI), University Medical Center of the Johannes Gutenberg-University, 55131 Mainz, Germany.
9Helmholtz Virtual Institute on Viral Strategies of Immune Evasion (VISTRIE), Helmholtz Centre for Infection Research, 38124 Braunschweig, Germany.
Stanley R. Riddell
2Focus Group “Clinical Cell Processing and Purification,” Institute for Advanced Study, Technische Universität München, 81675 Munich, Germany.
10Program in Immunology, Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
10Program in Immunology, Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Dirk H. Busch
1Institute for Medical Microbiology, Immunology and Hygiene, Technische Universität München, 81675 Munich, Germany.
2Focus Group “Clinical Cell Processing and Purification,” Institute for Advanced Study, Technische Universität München, 81675 Munich, Germany.
6Clinical Cooperation Groups “Antigen-specific Immunotherapy” and “Immune Monitoring,” Helmholtz Center Munich (85764 Neuherberg) and Technische Universität München, 81675 Munich, Germany.
7DZIF–National Centre for Infection Research, 81675 Munich, Germany.
Submit a Response to This Article
No eLetters have been published for this article.