Research ArticleImmunology

TCR-Ligand koff Rate Correlates with the Protective Capacity of Antigen-Specific CD8+ T Cells for Adoptive Transfer

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Science Translational Medicine  03 Jul 2013:
Vol. 5, Issue 192, pp. 192ra87
DOI: 10.1126/scitranslmed.3005958

Article Information

vol. 5 no. 192 192ra87

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication February 19, 2013
  • Accepted for publication April 30, 2013
  • .

Author Information

  1. Magdalena Nauerth1,*,
  2. Bianca Weißbrich1,*,
  3. Robert Knall1,*,
  4. Tobias Franz1,
  5. Georg Dössinger1,
  6. Jeannette Bet1,2,
  7. Paulina J. Paszkiewicz1,2,
  8. Lukas Pfeifer1,
  9. Mario Bunse3,4,
  10. Wolfgang Uckert3,4,
  11. Rafaela Holtappels5,
  12. Dorothea Gillert-Marien5,
  13. Michael Neuenhahn1,6,7,
  14. Angela Krackhardt6,8,
  15. Matthias J. Reddehase5,9,
  16. Stanley R. Riddell2,10,11 and
  17. Dirk H. Busch1,2,6,7,
  1. 1Institute for Medical Microbiology, Immunology and Hygiene, Technische Universität München, 81675 Munich, Germany.
  2. 2Focus Group “Clinical Cell Processing and Purification,” Institute for Advanced Study, Technische Universität München, 81675 Munich, Germany.
  3. 3Max Delbrück Center for Molecular Medicine, 13125 Berlin, Germany.
  4. 4Humboldt-Universität Berlin, 10099 Berlin, Germany.
  5. 5Institute for Virology and Research Center for Immunology (FZI), University Medical Center of the Johannes Gutenberg-University, 55131 Mainz, Germany.
  6. 6Clinical Cooperation Groups “Antigen-specific Immunotherapy” and “Immune Monitoring,” Helmholtz Center Munich (85764 Neuherberg) and Technische Universität München, 81675 Munich, Germany.
  7. 7DZIF–National Centre for Infection Research, 81675 Munich, Germany.
  8. 8Medical Department III, Hematology and Oncology, Technische Universität München, 81675 Munich, Germany.
  9. 9Helmholtz Virtual Institute on Viral Strategies of Immune Evasion (VISTRIE), Helmholtz Centre for Infection Research, 38124 Braunschweig, Germany.
  10. 10Program in Immunology, Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
  11. 11Department of Medicine, University of Washington, Seattle, WA 98104, USA.
  1. Corresponding author. E-mail: dirk.busch{at}mikrobio.med.tum.de
  • * These authors contributed equally to this work.

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