Contents
Vol 5, Issue 192
Contents
Editorial
- AMP v. Myriad: A Surgical Strike on Blockbuster Business Models
The U.S. Supreme Court’s decision in the Myriad Genetics case will promote translation of genetics-based diagnostics while preserving patent protection for other biomedical products.
Focus
- The Good and the Bad of Antibiotics
Bactericidal antibiotics induce generation of mitochondrial reactive oxygen species in mammalian cells (Kalghatgi et al., this issue).
Research Articles
- Bactericidal Antibiotics Induce Mitochondrial Dysfunction and Oxidative Damage in Mammalian Cells
Mitochondrial dysfunction and oxidative damage induced by bactericidal antibiotics in mammalian cells may be alleviated by an antioxidant or prevented by preferential use of bacteriostatic antibiotics.
- Natural Selection in a Bangladeshi Population from the Cholera-Endemic Ganges River Delta
Natural selection in a Bangladeshi population from the cholera-endemic Ganges River Delta has targeted genes associated with cholera resistance and an innate immunity pathway activated by Vibrio cholerae.
- TCR-Ligand koff Rate Correlates with the Protective Capacity of Antigen-Specific CD8+ T Cells for Adoptive Transfer
A Streptamer-based koff rate assay identifies T cells with high protective capacity for the adoptive transfer.
Editors' Choice
- A Molecular Meeting
A human genetic polymorphism that enhances insulin secretion illuminates a mechanistic link between cancer and type 2 diabetes.
- Modifying Genetic Disease
A new study identifies modifier genes for ataxin 1 in spinocerebellar ataxia and a strategy for treating such genetic diseases.
- Can Anti-Inflammatory Drugs Fight Infection?
Treatment with the anti-inflammatory drug ibuprofen decreased lung lesions and improved survival in a mouse model of tuberculosis.
- XiAP-ping Castration-Resistant Prostate Cancer
The XAF1-XIAP pathway provides a mechanistic link and a path for personalized prostate cancer therapy.
Erratum
