Research ArticleDiabetes

Plasmid-Encoded Proinsulin Preserves C-Peptide While Specifically Reducing Proinsulin-Specific CD8+ T Cells in Type 1 Diabetes

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Science Translational Medicine  26 Jun 2013:
Vol. 5, Issue 191, pp. 191ra82
DOI: 10.1126/scitranslmed.3006103

Article Information

vol. 5 no. 191 191ra82

PubMed: 
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History: 
  • Received for publication March 8, 2013
  • Accepted for publication May 10, 2013

Author Information

  1. Bart O. Roep1,*,
  2. Nanette Solvason2,3,*,
  3. Peter A. Gottlieb4,*,
  4. Joana R. F. Abreu1,
  5. Leonard C. Harrison5,
  6. George S. Eisenbarth4,,
  7. Liping Yu4,
  8. Michael Leviten2,
  9. William A. Hagopian6,
  10. John B. Buse7,
  11. Matthias von Herrath8,
  12. Joanne Quan2,
  13. Robert S. King2,
  14. William H. Robinson2,9,10,,
  15. Paul J. Utz2,9,10,
  16. Hideki Garren2,10,
  17. The BHT-3021 Investigators§ and
  18. Lawrence Steinman2,9,10,
  1. 1Department for Immunohematology and Blood Transfusion, Leiden University Medical Center, 2333 ZA Leiden, the Netherlands.
  2. 2Bayhill Therapeutics, Palo Alto, CA 94304, USA.
  3. 3Foothill College, Los Altos, CA 94022, USA
  4. 4Barbara Davis Center for Childhood Diabetes, Aurora, CO 80045–6511, USA.
  5. 5Division of Molecular Medicine, Walter and Eliza Hall Institute for Medical Research, Parkville, Victoria 3052, Australia.
  6. 6Pacific Northwest Diabetes Research Institute and University of Washington, Seattle, WA 98122, USA.
  7. 7Diabetes Center for Research, University of North Carolina, Chapel Hill, NC 27599, USA.
  8. 8La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA.
  9. 9Departments of Medicine and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA.
  10. 10Tolerion Inc., 321 Dedalera Drive, Portola Valley, CA, USA.
  1. Corresponding author. E-mail: steinman{at}stanford.edu (L.S.); wrobins{at}stanford.edu (W.H.R.)
  • * These authors contributed equally to this work.

  • Deceased.

  • § United States: P. Gottlieb, Denver, CO; J. Skyler, Miami, FL; R. Hays, Wellington, FL; F. Ovalle, Birmingham, AL; V. Aroda/R. Ratner, Washington, DC; J. Berg/M. Kipnes, San Antonio, TX; L. Zemel, Denver, CO; M. Rendell, Omaha, NE; P. Norwood, Fresno, CA; P. Raskin, Dallas, TX. Australia/New Zealand: P. Colman, Melbourne; M. Gerstman, Victoria; T. Davis, Fremantle; V. Heazlewood, Queensland; J. Baker, Auckland; P. Dunn, Hamilton; R. Scott, Christchurch; J. Krebs, Wellington. ClinicalTrials.gov registration number: NCT00453375.

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