Research ArticleAlzheimer’s Disease

Increased in Vivo Amyloid-β42 Production, Exchange, and Loss in Presenilin Mutation Carriers

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Science Translational Medicine  12 Jun 2013:
Vol. 5, Issue 189, pp. 189ra77
DOI: 10.1126/scitranslmed.3005615

Article Information

vol. 5 no. 189 189ra77

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication December 31, 2012
  • Accepted for publication May 24, 2013
  • .

Author Information

  1. Rachel Potter1,*,
  2. Bruce W. Patterson2,*,
  3. Donald L. Elbert3,
  4. Vitaliy Ovod1,
  5. Tom Kasten1,
  6. Wendy Sigurdson1,4,
  7. Kwasi Mawuenyega1,
  8. Tyler Blazey4,5,
  9. Alison Goate4,6,7,
  10. Robert Chott2,
  11. Kevin E. Yarasheski2,
  12. David M. Holtzman1,4,6,
  13. John C. Morris1,4,6,
  14. Tammie L. S. Benzinger4,5,8 and
  15. Randall J. Bateman1,4,6,
  1. 1Department of Neurology, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, USA.
  2. 2Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
  3. 3Department of Biomedical Engineering, Washington University in St. Louis, One Brookings Drive, St. Louis, MO 63130, USA.
  4. 4Knight Alzheimer’s Disease Research Center, Washington University School of Medicine, St. Louis, MO 63110, USA.
  5. 5Department of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
  6. 6Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO 63110, USA.
  7. 7Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA.
  8. 8Department of Neurological Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA.
  1. Corresponding author. E-mail: batemanr{at}wustl.edu
  • * These authors contributed equally to this work.

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