Antigen-Specific Tolerance by Autologous Myelin Peptide–Coupled Cells: A Phase 1 Trial in Multiple Sclerosis

Andreas Lutterotti; Sara Yousef; Andreas Sputtek; Klarissa H. Stürner; Jan-Patrick Stellmann; Petra Breiden; Stefanie Reinhardt; Christian Schulze; Maxim Bester; Christoph Heesen; Sven Schippling; Stephen D. Miller; Mireia Sospedra; Roland Martin

doi:10.1126/scitranslmed.3006168

Research ArticleMultiple Sclerosis

Antigen-Specific Tolerance by Autologous Myelin Peptide–Coupled Cells: A Phase 1 Trial in Multiple Sclerosis

Andreas Lutterotti¹,²,
Sara Yousef¹,
Andreas Sputtek³,
Klarissa H. Stürner¹,
Jan-Patrick Stellmann¹,
Petra Breiden¹,
Stefanie Reinhardt¹,
Christian Schulze⁴,
Maxim Bester⁵,
Christoph Heesen¹,
Sven Schippling¹,⁶,
Stephen D. Miller⁷,*,
Mireia Sospedra¹,⁶,* and
Roland Martin¹,⁶,*,†

¹Institute for Neuroimmunology and Clinical MS Research, Center for Molecular Neurobiology, 20251 Hamburg, Germany.
²Clinical Department of Neurology, Innsbruck Medical University, 6020 Innsbruck, Austria.
³Institute of Transfusion Medicine, Center for Diagnostics, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
⁴Systems Biology and Protein-Protein Interaction, Center for Molecular Neurobiology, 20251 Hamburg, Germany.
⁵Department of Diagnostic and Interventional Neuroradiology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
⁶Neuroimmunology and MS Research, Department of Neurology, University Hospital Zürich, 8091 Zürich, Switzerland.
⁷Department of Microbiology-Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.

↵†Corresponding author. E-mail: roland.martin{at}usz.ch

↵* These authors contributed equally to this work.

See allHide authors and affiliations

Science Translational Medicine 05 Jun 2013:
Vol. 5, Issue 188, pp. 188ra75
DOI: 10.1126/scitranslmed.3006168

Andreas Lutterotti

Institute for Neuroimmunology and Clinical MS Research, Center for Molecular Neurobiology, 20251 Hamburg, Germany.Clinical Department of Neurology, Innsbruck Medical University, 6020 Innsbruck, Austria.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Sara Yousef

Institute for Neuroimmunology and Clinical MS Research, Center for Molecular Neurobiology, 20251 Hamburg, Germany.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Andreas Sputtek

Institute of Transfusion Medicine, Center for Diagnostics, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Klarissa H. Stürner

Institute for Neuroimmunology and Clinical MS Research, Center for Molecular Neurobiology, 20251 Hamburg, Germany.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Jan-Patrick Stellmann

Institute for Neuroimmunology and Clinical MS Research, Center for Molecular Neurobiology, 20251 Hamburg, Germany.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Petra Breiden

Institute for Neuroimmunology and Clinical MS Research, Center for Molecular Neurobiology, 20251 Hamburg, Germany.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Stefanie Reinhardt

Institute for Neuroimmunology and Clinical MS Research, Center for Molecular Neurobiology, 20251 Hamburg, Germany.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Christian Schulze

Systems Biology and Protein-Protein Interaction, Center for Molecular Neurobiology, 20251 Hamburg, Germany.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Maxim Bester

Department of Diagnostic and Interventional Neuroradiology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Christoph Heesen

Institute for Neuroimmunology and Clinical MS Research, Center for Molecular Neurobiology, 20251 Hamburg, Germany.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Sven Schippling

Institute for Neuroimmunology and Clinical MS Research, Center for Molecular Neurobiology, 20251 Hamburg, Germany.Neuroimmunology and MS Research, Department of Neurology, University Hospital Zürich, 8091 Zürich, Switzerland.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Stephen D. Miller

Department of Microbiology-Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Mireia Sospedra

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Roland Martin

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
For correspondence: roland.martin@usz.ch

Article
Figures & Data
Info & Metrics
eLetters
PDF

eLetters is an online forum for ongoing peer review. Submission of eLetters are open to all. Please read our Terms of Service before submitting your own eLetter.

Submit a Response to This Article

Compose eLetter

Title

Contents

More information about text formats

Plain text

Plain text
No HTML tags allowed.
Web page addresses and e-mail addresses turn into links automatically.
Lines and paragraphs break automatically.

Author Information

Contributors
First name and middle name First or given name, e.g. 'Peter'. Last Name Your last, or family, name, e.g. 'MacMoody'. Email Your email address, e.g. higgs-boson@gmail.com Role / Occupation Your role and/or occupation, e.g. 'Orthopedic Surgeon'. Affiliation Your organization or institution (if applicable), e.g. 'Royal Free Hospital'.

Statement of Competing Interests

Competing interests?

Yes

Please describe the competing interests

CAPTCHA

This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

What code is in the image? Enter the characters shown in the image.

Vertical Tabs

No eLetters have been published for this article.

View Full Text

Antigen-Specific Tolerance by Autologous Myelin Peptide–Coupled Cells: A Phase 1 Trial in Multiple Sclerosis

Plain text

Vertical Tabs

Science Translational Medicine

Article Tools