Antigen-Specific Tolerance by Autologous Myelin Peptide–Coupled Cells: A Phase 1 Trial in Multiple Sclerosis

Andreas Lutterotti; Sara Yousef; Andreas Sputtek; Klarissa H. Stürner; Jan-Patrick Stellmann; Petra Breiden; Stefanie Reinhardt; Christian Schulze; Maxim Bester; Christoph Heesen; Sven Schippling; Stephen D. Miller; Mireia Sospedra; Roland Martin

doi:10.1126/scitranslmed.3006168

Research ArticleMultiple Sclerosis

Antigen-Specific Tolerance by Autologous Myelin Peptide–Coupled Cells: A Phase 1 Trial in Multiple Sclerosis

Andreas Lutterotti¹,²,
Sara Yousef¹,
Andreas Sputtek³,
Klarissa H. Stürner¹,
Jan-Patrick Stellmann¹,
Petra Breiden¹,
Stefanie Reinhardt¹,
Christian Schulze⁴,
Maxim Bester⁵,
Christoph Heesen¹,
Sven Schippling¹,⁶,
Stephen D. Miller⁷,*,
Mireia Sospedra¹,⁶,* and
Roland Martin¹,⁶,*,†

¹Institute for Neuroimmunology and Clinical MS Research, Center for Molecular Neurobiology, 20251 Hamburg, Germany.
²Clinical Department of Neurology, Innsbruck Medical University, 6020 Innsbruck, Austria.
³Institute of Transfusion Medicine, Center for Diagnostics, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
⁴Systems Biology and Protein-Protein Interaction, Center for Molecular Neurobiology, 20251 Hamburg, Germany.
⁵Department of Diagnostic and Interventional Neuroradiology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
⁶Neuroimmunology and MS Research, Department of Neurology, University Hospital Zürich, 8091 Zürich, Switzerland.
⁷Department of Microbiology-Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.

↵†Corresponding author. E-mail: roland.martin{at}usz.ch

↵* These authors contributed equally to this work.

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Science Translational Medicine 05 Jun 2013:
Vol. 5, Issue 188, pp. 188ra75
DOI: 10.1126/scitranslmed.3006168

Andreas Lutterotti

1Institute for Neuroimmunology and Clinical MS Research, Center for Molecular Neurobiology, 20251 Hamburg, Germany.

2Clinical Department of Neurology, Innsbruck Medical University, 6020 Innsbruck, Austria.

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Sara Yousef

1Institute for Neuroimmunology and Clinical MS Research, Center for Molecular Neurobiology, 20251 Hamburg, Germany.

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Andreas Sputtek

3Institute of Transfusion Medicine, Center for Diagnostics, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.

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Klarissa H. Stürner

1Institute for Neuroimmunology and Clinical MS Research, Center for Molecular Neurobiology, 20251 Hamburg, Germany.

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Jan-Patrick Stellmann

1Institute for Neuroimmunology and Clinical MS Research, Center for Molecular Neurobiology, 20251 Hamburg, Germany.

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Petra Breiden

1Institute for Neuroimmunology and Clinical MS Research, Center for Molecular Neurobiology, 20251 Hamburg, Germany.

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Stefanie Reinhardt

1Institute for Neuroimmunology and Clinical MS Research, Center for Molecular Neurobiology, 20251 Hamburg, Germany.

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Christian Schulze

4Systems Biology and Protein-Protein Interaction, Center for Molecular Neurobiology, 20251 Hamburg, Germany.

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Maxim Bester

5Department of Diagnostic and Interventional Neuroradiology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.

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Christoph Heesen

1Institute for Neuroimmunology and Clinical MS Research, Center for Molecular Neurobiology, 20251 Hamburg, Germany.

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Sven Schippling

1Institute for Neuroimmunology and Clinical MS Research, Center for Molecular Neurobiology, 20251 Hamburg, Germany.

6Neuroimmunology and MS Research, Department of Neurology, University Hospital Zürich, 8091 Zürich, Switzerland.

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Stephen D. Miller

7Department of Microbiology-Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.

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Mireia Sospedra

1Institute for Neuroimmunology and Clinical MS Research, Center for Molecular Neurobiology, 20251 Hamburg, Germany.

6Neuroimmunology and MS Research, Department of Neurology, University Hospital Zürich, 8091 Zürich, Switzerland.

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Roland Martin

1Institute for Neuroimmunology and Clinical MS Research, Center for Molecular Neurobiology, 20251 Hamburg, Germany.

6Neuroimmunology and MS Research, Department of Neurology, University Hospital Zürich, 8091 Zürich, Switzerland.

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For correspondence: roland.martin@usz.ch

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Antigen-Specific Tolerance by Autologous Myelin Peptide–Coupled Cells: A Phase 1 Trial in Multiple Sclerosis

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