Comment on “Drug Screening for ALS Using Patient-Specific Induced Pluripotent Stem Cells”

Bilada Bilican; Andrea Serio; Sami J. Barmada; Agnes Lumi Nishimura; Gareth J. Sullivan; Monica Carrasco; Hemali P. Phatnani; Clare A. Puddifoot; David Story; Judy Fletcher; In-Hyun Park; Brad A. Friedman; George Q. Daley; David J. A. Wyllie; Giles E. Hardingham; Ian Wilmut; Steven Finkbeiner; Tom Maniatis; Christopher E. Shaw; Siddharthan Chandran

doi:10.1126/scitranslmed.3005065

LetterStem Cells

Comment on “Drug Screening for ALS Using Patient-Specific Induced Pluripotent Stem Cells”

Bilada Bilican¹,²,
Andrea Serio¹,²,
Sami J. Barmada³,⁴,
Agnes Lumi Nishimura⁵,
Gareth J. Sullivan²,
Monica Carrasco⁶,
Hemali P. Phatnani⁶,
Clare A. Puddifoot⁷,
David Story¹,²,
Judy Fletcher²,
In-Hyun Park⁸,
Brad A. Friedman⁹,
George Q. Daley¹⁰,
David J. A. Wyllie⁷,
Giles E. Hardingham⁷,
Ian Wilmut²,
Steven Finkbeiner³,⁴,
Tom Maniatis⁶,
Christopher E. Shaw⁵ and
Siddharthan Chandran¹,²,¹¹,*

¹Euan MacDonald Centre for Motor Neurone Disease Research, University of Edinburgh, Edinburgh EH16 4SB, UK.
²Medical Research Council Centre for Regenerative Medicine, University of Edinburgh, Edinburgh EH16 4SB, UK.
³Taube-Koret Center, Hellman Program, and Rodenberry Stem Cell Program, Gladstone Institute of Neurological Disease, San Francisco, CA 94158, USA.
⁴Departments of Neurology and Physiology, University of California, San Francisco, San Francisco, CA 94143, USA.
⁵Institute of Psychiatry, Medical Research Council Centre for Neurodegeneration Research, King’s College London, London SE5 8AF, UK.
⁶Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA.
⁷Centre for Integrative Physiology, University of Edinburgh, Edinburgh EH8 9XD, UK.
⁸Yale Stem Cell Center, Department of Genetics, Yale School of Medicine, New Haven, CT 06520, USA.
⁹Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA.
¹⁰Department of Biological Chemistry and Molecular Pharmacology, Harvard Stem Cell Institute, Harvard Medical School, Boston, MA 02115, USA.
¹¹Centre for Neuroregeneration, University of Edinburgh, Edinburgh EH16 4SB, UK.

↵*Corresponding author. E-mail: siddharthan.chandran{at}ed.ac.uk

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Science Translational Medicine 05 Jun 2013:
Vol. 5, Issue 188, pp. 188le2
DOI: 10.1126/scitranslmed.3005065

Bilada Bilican

Euan MacDonald Centre for Motor Neurone Disease Research, University of Edinburgh, Edinburgh EH16 4SB, UK.Medical Research Council Centre for Regenerative Medicine, University of Edinburgh, Edinburgh EH16 4SB, UK.

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Andrea Serio

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Sami J. Barmada

Taube-Koret Center, Hellman Program, and Rodenberry Stem Cell Program, Gladstone Institute of Neurological Disease, San Francisco, CA 94158, USA.Departments of Neurology and Physiology, University of California, San Francisco, San Francisco, CA 94143, USA.

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Agnes Lumi Nishimura

Institute of Psychiatry, Medical Research Council Centre for Neurodegeneration Research, King’s College London, London SE5 8AF, UK.

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Gareth J. Sullivan

Medical Research Council Centre for Regenerative Medicine, University of Edinburgh, Edinburgh EH16 4SB, UK.

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Monica Carrasco

Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA.

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Hemali P. Phatnani

Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA.

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Clare A. Puddifoot

Centre for Integrative Physiology, University of Edinburgh, Edinburgh EH8 9XD, UK.

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David Story

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Judy Fletcher

Medical Research Council Centre for Regenerative Medicine, University of Edinburgh, Edinburgh EH16 4SB, UK.

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In-Hyun Park

Yale Stem Cell Center, Department of Genetics, Yale School of Medicine, New Haven, CT 06520, USA.

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Brad A. Friedman

Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA.

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George Q. Daley

Department of Biological Chemistry and Molecular Pharmacology, Harvard Stem Cell Institute, Harvard Medical School, Boston, MA 02115, USA.

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David J. A. Wyllie

Centre for Integrative Physiology, University of Edinburgh, Edinburgh EH8 9XD, UK.

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Giles E. Hardingham

Centre for Integrative Physiology, University of Edinburgh, Edinburgh EH8 9XD, UK.

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Ian Wilmut

Medical Research Council Centre for Regenerative Medicine, University of Edinburgh, Edinburgh EH16 4SB, UK.

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Steven Finkbeiner

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Tom Maniatis

Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA.

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Christopher E. Shaw

Institute of Psychiatry, Medical Research Council Centre for Neurodegeneration Research, King’s College London, London SE5 8AF, UK.

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Siddharthan Chandran

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For correspondence: siddharthan.chandran@ed.ac.uk

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Abstract

Egawa et al. recently showed the value of patient-specific induced pluripotent stem cells (iPSCs) for modeling amyotrophic lateral sclerosis in vitro. Their study and our work highlight the need for complementary assays to detect small, but potentially important, phenotypic differences between control iPSC lines and those carrying disease mutations.

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Comment on “Drug Screening for ALS Using Patient-Specific Induced Pluripotent Stem Cells”

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Science Translational Medicine

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