Contents
Vol 5, Issue 188
Contents
Focus
- One Is Better than Two: TCR Pairing and GVHD
T lymphocytes that express dual TCRs are found more frequently in patients with acute graft-versus-host disease (GVHD) (Morris et al., this issue).
- Preventing the Pain of PTSD
A selective opioid receptor agonist prevents fear memory consolidation in the amygdala in a mouse model of posttraumatic stress disorder (Andero et al., in this issue).
Research Articles
- Amygdala-Dependent Fear Is Regulated by Oprl1 in Mice and Humans with PTSD
An agonist of the opioid receptor–like 1 protein may ameliorate the symptoms of posttraumatic stress disorder if given shortly after exposure to a traumatic event.
- Dual Receptor T Cells Mediate Pathologic Alloreactivity in Patients with Acute Graft-Versus-Host Disease
Expansion of dual TCR T cells in patients after HSC transplantation is significantly associated with acute GVHD.
- Antigen-Specific Tolerance by Autologous Myelin Peptide–Coupled Cells: A Phase 1 Trial in Multiple Sclerosis
Antigen-coupled cells result in antigen-specific tolerization for treatment of multiple sclerosis.
Editors' Choice
- T Cells Take Notice of Distinct Mutations in Cancer Cells
Cancer-specific mutations in melanoma are recognized by tumor-infiltrating T cells and may explain the clinical activity of some immunotherapies.
- The Source of Youth and Longevity Revealed?
The hypothalamus controls whole-body aging via immune-neuroendocrine mechanisms.
- Keeping Metastasis at Bay
A small therapeutic peptide may induce a tumor-suppressive response at metastatic sites.
- A Coat Connects Obesity with Heart Disease
Perivascular adipose tissue surrounding coronary arteries may contribute to heart disease.
Letters
