05 June 2013
Vol 5, Issue 188

About The Cover

Cover image expansion

ONLINE COVER Two of a Kind? Shown is a dual T cell receptor (TCR) T cell. Most T cells express TCRs of one specificity; however, a small subset of T cells expresses two different TCRs. These TCRs are composed of a shared β chain (blue) combined with one of two different α chains (red and orange). Morris et al. now demonstrate that this relatively rare subset of T cells contributes disproportionately to graft-versus-host disease (GVHD) in patients. These cells may serve as markers for GVHD or may be targeted to decrease the risk of graft recipients developing GVHD. [CREDIT: C. BICKEL/SCIENCE TRANSLATIONAL MEDICINE]