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Research ArticleProstate Cancer
A Preclinical Xenograft Model Identifies Castration-Tolerant Cancer-Repopulating Cells in Localized Prostate Tumors
- Roxanne Toivanen1,
- Mark Frydenberg1,2,
- Declan Murphy3,
- John Pedersen1,4,
- Andrew Ryan4,
- David Pook1,
- David M. Berman5,
- Australian Prostate Cancer BioResource1,
- Renea A. Taylor1,6,* and
- Gail P. Risbridger1,*,†
- 1Department of Anatomy and Developmental Biology, Monash University, Clayton, Victoria 3800, Australia.
- 2Department of Surgery, Monash University, Clayton, Victoria 3800, Australia.
- 3Division of Cancer Surgery, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3800, Australia.
- 4TissuPath Laboratories, Mount Waverley, Victoria 3149, Australia.
- 5Department of Pathology and Molecular Medicine, Queen’s University, Kingston, Ontario K7L 3N6, Canada.
- 6Department of Physiology, Monash University, Clayton, Victoria 3800, Australia.
- ↵†Corresponding author. E-mail: gail.risbridger{at}monash.edu
-
↵* These authors contributed equally to this work.
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Science Translational Medicine 29 May 2013:
Vol. 5, Issue 187, pp. 187ra71
DOI: 10.1126/scitranslmed.3005688
Vol. 5, Issue 187, pp. 187ra71
DOI: 10.1126/scitranslmed.3005688
Roxanne Toivanen
1Department of Anatomy and Developmental Biology, Monash University, Clayton, Victoria 3800, Australia.
Mark Frydenberg
1Department of Anatomy and Developmental Biology, Monash University, Clayton, Victoria 3800, Australia.
2Department of Surgery, Monash University, Clayton, Victoria 3800, Australia.
Declan Murphy
3Division of Cancer Surgery, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3800, Australia.
John Pedersen
1Department of Anatomy and Developmental Biology, Monash University, Clayton, Victoria 3800, Australia.
4TissuPath Laboratories, Mount Waverley, Victoria 3149, Australia.
Andrew Ryan
4TissuPath Laboratories, Mount Waverley, Victoria 3149, Australia.
David Pook
1Department of Anatomy and Developmental Biology, Monash University, Clayton, Victoria 3800, Australia.
David M. Berman
5Department of Pathology and Molecular Medicine, Queen’s University, Kingston, Ontario K7L 3N6, Canada.
1Department of Anatomy and Developmental Biology, Monash University, Clayton, Victoria 3800, Australia.
Renea A. Taylor
1Department of Anatomy and Developmental Biology, Monash University, Clayton, Victoria 3800, Australia.
6Department of Physiology, Monash University, Clayton, Victoria 3800, Australia.
Gail P. Risbridger
1Department of Anatomy and Developmental Biology, Monash University, Clayton, Victoria 3800, Australia.
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