Contents
Vol 5, Issue 187
Contents
Focus
- Cardio-Oncology: It Takes Two to Translate
Heart-related toxicities from targeted cancer therapies shed light on the biology of cardiovascular disease in humans (Chintalgattu et al., this issue).
Perspective
- Clinically Relevant Modeling of Tumor Growth and Treatment Response
Noninvasive imaging technologies can help create patient-specific mathematical models to predict tumor growth.
Research Articles
- Coronary Microvascular Pericytes Are the Cellular Target of Sunitinib Malate–Induced Cardiotoxicity
Sunitinib-induced cardiotoxicity is caused by depletion of coronary pericytes due to loss of PDGFR signaling; this side effect can be prevented by thalidomide.
- Glycosylations in the Globular Head of the Hemagglutinin Protein Modulate the Virulence and Antigenic Properties of the H1N1 Influenza Viruses
Hemagglutinin glycosylations modulate the virulence and antigenicity of H1N1 influenza viruses.
- A Preclinical Xenograft Model Identifies Castration-Tolerant Cancer-Repopulating Cells in Localized Prostate Tumors
This study uses a preclinical xenograft model to reveal prostate cancer cells that exist in untreated localized disease, survive androgen withdrawal, and are potential therapeutic targets.
- Intranasal Antibody Gene Transfer in Mice and Ferrets Elicits Broad Protection Against Pandemic Influenza
Intranasal delivery of a broadly neutralizing antibody to influenza by an AAV9 vector affords complete protection.
Editors' Choice
- Sugar Coat It
Rational biomaterial design mimics the body’s mechanism for regulating glucose levels and thus controlling diabetes.
- One More Reason to Love Mother’s Milk
Breast milk–derived sodium nitrate provides an exogenous source of nitric oxide that protects against ischemia in necrotizing enterocolitis.
- A Field Trip to Plasticity
Exploration benefits brain plasticity and personalizes behavior.
- Tracking Tolerance—T Regulatory Type 1 Cell Markers Revealed
LAG-3 and CD49b are cell surface markers of type 1 regulatory T cells.
Erratum
