Research ArticleINFERTILITY

Cyclophosphamide Triggers Follicle Activation and “Burnout”; AS101 Prevents Follicle Loss and Preserves Fertility

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Science Translational Medicine  15 May 2013:
Vol. 5, Issue 185, pp. 185ra62
DOI: 10.1126/scitranslmed.3005402

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  • Gonadotoxic effect of chemotherapy

    Kalich-Philosoph et al are congratulated for their fine publication. The mechanism they describe as "burn-out" has been similarly suggested by us, a few years ago[1-4], explaining how the administration of gonadotropin-releasing hormone agonists [GnRHa] may possibly prevent follicular demise and minimize the chemotherapy induced gonadotoxicity. In brief,the hypogonadotropic state, generated by GnRHa, simulates a prepuber...

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    Competing Interests: None declared.