15 May 2013
Vol 5, Issue 185
  • Contents

    • Perspective

      • The Gracefully Aging Immune System

        Strategies are being developed to overcome aging-associated changes in the immune response.

    • Research Articles

    • Editors' Choice

      • Engineering Blood Vessels Through Geometry

        Providing endothelial cells with a prefixed template enhances neovessel formation and promotes integration within engineered tissues.

      • Now You See Me, Now You Don’t

        Computer-aided design helps nanoparticles escape recognition and uptake by macrophages.

      • The Brains Behind Alcohol Relapse

        Investigators identify neural markers that may predict correlate with relapse to alcohol use in humans.

About The Cover

Cover image expansion

ONLINE COVER Influencing Immunity. Ribbon diagram of the mouse toll-like receptor (TLR) coreceptor CD14  (shown). Raby et al. demonstrate that a peptide targeting CD14 enhanced TLR-induced proinflammatory responses and could restore the immune response in cells from immunosuppressed sepsis patients. [CREDIT: C. BICKEL/SCIENCE TRANSLATIONAL MEDICINE]