Contents
Vol 5, Issue 185
Contents
Perspective
- The Gracefully Aging Immune System
Strategies are being developed to overcome aging-associated changes in the immune response.
Research Articles
- Cyclophosphamide Triggers Follicle Activation and “Burnout”; AS101 Prevents Follicle Loss and Preserves Fertility
Cyclophosphamide activates dormant follicle growth, leading to depletion of ovarian reserve, and AS101 prevents this activation, rescuing fertility in mice.
- Oncolytic and Immunotherapeutic Vaccinia Induces Antibody-Mediated Complement-Dependent Cancer Cell Lysis in Humans
The oncolytic and immunotherapeutic vaccinia virus Pexa-Vec (JX-594) induces antibody-mediated complement-dependent cancer cell cytolysis in rabbits and cancer patients, prolonging their survival.
- Targeting the TLR Co-Receptor CD14 with TLR2-Derived Peptides Modulates Immune Responses to Pathogens
Toll-like receptor–mediated responses to pathogens can be modulated by targeting the TLR co-receptor CD14.
- Synthetic Generation of Influenza Vaccine Viruses for Rapid Response to Pandemics
Synthesis of viral genes from sequence information allows rapid generation of influenza vaccine viruses, facilitating rapid responses to influenza pandemics.
Editors' Choice
- Engineering Blood Vessels Through Geometry
Providing endothelial cells with a prefixed template enhances neovessel formation and promotes integration within engineered tissues.
- Now You See Me, Now You Don’t
Computer-aided design helps nanoparticles escape recognition and uptake by macrophages.
- The Brains Behind Alcohol Relapse
Investigators identify neural markers that may predict correlate with relapse to alcohol use in humans.
- Bringing Down the House by Targeting the Scaffold
The scaffold protein IQGAP1 coordinates MAPK signaling and is a therapeutic target for RAS driven cancers
