Contents
Vol 5, Issue 184
Contents
Focus
- Ethics, Error, and Initial Trials of Efficacy
Clinical trial reforms aimed at boosting phase 2 positive predictivity may entail ethical and social trade-offs.
- Blocking the Spread of Resistance
Understanding how Staphylococcus aureus is involved in conjugative plasmid transfer may lead to new strategies to combat antimicrobial resistance.
Research Articles
- Neural Stem Cell–Mediated Enzyme/Prodrug Therapy for Glioma: Preclinical Studies
Neural stem cells home to gliomas in mice where they convert a prodrug to 5-fluorouracil, leading to tumor regression.
- Genomic Diversity and Fitness of E. coli Strains Recovered from the Intestinal and Urinary Tracts of Women with Recurrent Urinary Tract Infection
Comparative genomic and functional studies reveal that E. coli strains from women with recurrent urinary tract infection can move between gut and urinary tract without a fitness trade-off.
- Targeted Imaging of Esophageal Neoplasia with a Fluorescently Labeled Peptide: First-in-Human Results
A fluorescently labeled peptide enables first-in-human targeted endoscopic imaging of esophageal neoplasia.
Editors' Choice
- Demystifying the “Magical Cure” for Diabetes
Rapid improvements in glucose tolerance within three weeks of Roux-en-Y-gastric bypass surgery may be largely due to caloric restriction.
- Cancer Therapeutics: Best Informed by Genes or Genomes?
General genomic features such as mutation frequency and copy number variation define prognosis-related classes of endometrial carcinoma better than mutations in cancer genes.
- Nano Decoy Tricks Venom
Tiny particles covered with red blood cell membranes absorb pore-forming toxins and prolong survival in animals.
- Eavesdropping on Communications Between Liver and β Cells
A hormone expressed in liver and fat promotes pancreatic β cell proliferation, cell mass, and glucose tolerance in a mouse model.
