eLetters is an online forum for ongoing peer review. Submission of eLetters are open to all. Please read our Terms of Service before submitting your own eLetter.
Research ArticleTherapeutic Antibodies
Addressing Safety Liabilities of TfR Bispecific Antibodies That Cross the Blood-Brain Barrier
- Jessica A. Couch1,*,
- Y. Joy Yu2,*,
- Yin Zhang3,
- Jacqueline M. Tarrant1,
- Reina N. Fuji1,
- William J. Meilandt2,
- Hilda Solanoy2,
- Raymond K. Tong4,
- Kwame Hoyte5,
- Wilman Luk5,
- Yanmei Lu5,
- Kapil Gadkar1,
- Saileta Prabhu1,
- Benjamin A. Ordonia1,
- Quyen Nguyen1,
- Yuwen Lin1,
- Zhonghua Lin6,
- Mercedesz Balazs6,
- Kimberly Scearce-Levie2,
- James A. Ernst4,
- Mark S. Dennis3,† and
- Ryan J. Watts2,†
- 1Development Sciences, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
- 2Neurodegeneration Labs, Department of Neuroscience, Genentech Inc., South San Francisco, CA 94080, USA.
- 3Antibody Engineering, Genentech Inc., South San Francisco, CA 94080, USA.
- 4Protein Chemistry, Genentech Inc., South San Francisco, CA 94080, USA.
- 5Biochemical and Cellular Pharmacology, Genentech Inc., South San Francisco, CA 94080, USA.
- 6Translational Immunology, Genentech Inc., South San Francisco, CA 94080, USA.
- ↵†Corresponding author. E-mail: rwatts{at}gene.com (R.J.W.); msd{at}gene.com (M.S.D.)
-
↵* These authors contributed equally to this work.
See allHide authors and affiliations
Science Translational Medicine 01 May 2013:
Vol. 5, Issue 183, pp. 183ra57
DOI: 10.1126/scitranslmed.3005338
Vol. 5, Issue 183, pp. 183ra57
DOI: 10.1126/scitranslmed.3005338
Jessica A. Couch
Development Sciences, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
Y. Joy Yu
Neurodegeneration Labs, Department of Neuroscience, Genentech Inc., South San Francisco, CA 94080, USA.
Yin Zhang
Antibody Engineering, Genentech Inc., South San Francisco, CA 94080, USA.
Jacqueline M. Tarrant
Development Sciences, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
Reina N. Fuji
Development Sciences, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
William J. Meilandt
Neurodegeneration Labs, Department of Neuroscience, Genentech Inc., South San Francisco, CA 94080, USA.
Hilda Solanoy
Neurodegeneration Labs, Department of Neuroscience, Genentech Inc., South San Francisco, CA 94080, USA.
Raymond K. Tong
Protein Chemistry, Genentech Inc., South San Francisco, CA 94080, USA.
Kwame Hoyte
Biochemical and Cellular Pharmacology, Genentech Inc., South San Francisco, CA 94080, USA.
Wilman Luk
Biochemical and Cellular Pharmacology, Genentech Inc., South San Francisco, CA 94080, USA.
Yanmei Lu
Biochemical and Cellular Pharmacology, Genentech Inc., South San Francisco, CA 94080, USA.
Kapil Gadkar
Development Sciences, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
Saileta Prabhu
Development Sciences, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
Benjamin A. Ordonia
Development Sciences, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
Quyen Nguyen
Development Sciences, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
Yuwen Lin
Development Sciences, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
Zhonghua Lin
Translational Immunology, Genentech Inc., South San Francisco, CA 94080, USA.
Mercedesz Balazs
Translational Immunology, Genentech Inc., South San Francisco, CA 94080, USA.
Kimberly Scearce-Levie
Neurodegeneration Labs, Department of Neuroscience, Genentech Inc., South San Francisco, CA 94080, USA.
James A. Ernst
Protein Chemistry, Genentech Inc., South San Francisco, CA 94080, USA.
Mark S. Dennis
Antibody Engineering, Genentech Inc., South San Francisco, CA 94080, USA.
Ryan J. Watts
Neurodegeneration Labs, Department of Neuroscience, Genentech Inc., South San Francisco, CA 94080, USA.
Submit a Response to This Article
No eLetters have been published for this article.