Research ArticleTherapeutic Antibodies

Addressing Safety Liabilities of TfR Bispecific Antibodies That Cross the Blood-Brain Barrier

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Science Translational Medicine  01 May 2013:
Vol. 5, Issue 183, pp. 183ra57
DOI: 10.1126/scitranslmed.3005338

Article Information

vol. 5 no. 183 183ra57

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication November 13, 2012
  • Accepted for publication April 9, 2013
  • .

Author Information

  1. Jessica A. Couch1,*,
  2. Y. Joy Yu2,*,
  3. Yin Zhang3,
  4. Jacqueline M. Tarrant1,
  5. Reina N. Fuji1,
  6. William J. Meilandt2,
  7. Hilda Solanoy2,
  8. Raymond K. Tong4,
  9. Kwame Hoyte5,
  10. Wilman Luk5,
  11. Yanmei Lu5,
  12. Kapil Gadkar1,
  13. Saileta Prabhu1,
  14. Benjamin A. Ordonia1,
  15. Quyen Nguyen1,
  16. Yuwen Lin1,
  17. Zhonghua Lin6,
  18. Mercedesz Balazs6,
  19. Kimberly Scearce-Levie2,
  20. James A. Ernst4,
  21. Mark S. Dennis3, and
  22. Ryan J. Watts2,
  1. 1Development Sciences, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  2. 2Neurodegeneration Labs, Department of Neuroscience, Genentech Inc., South San Francisco, CA 94080, USA.
  3. 3Antibody Engineering, Genentech Inc., South San Francisco, CA 94080, USA.
  4. 4Protein Chemistry, Genentech Inc., South San Francisco, CA 94080, USA.
  5. 5Biochemical and Cellular Pharmacology, Genentech Inc., South San Francisco, CA 94080, USA.
  6. 6Translational Immunology, Genentech Inc., South San Francisco, CA 94080, USA.
  1. Corresponding author. E-mail: rwatts{at}gene.com (R.J.W.); msd{at}gene.com (M.S.D.)
  • * These authors contributed equally to this work.

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