Addressing Safety Liabilities of TfR Bispecific Antibodies That Cross the Blood-Brain Barrier

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  Addressing Safety Liabilities of TfR Bispecific Antibodies That Cross the Blood-Brain Barrier

  By Jessica A. Couch, Y. Joy Yu, Yin Zhang, Jacqueline M. Tarrant, Reina N. Fuji, William J. Meilandt, Hilda Solanoy, Raymond K. Tong, Kwame Hoyte, Wilman Luk, Yanmei Lu, Kapil Gadkar, Saileta Prabhu, Benjamin A. Ordonia, Quyen Nguyen, Yuwen Lin, Zhonghua Lin, Mercedesz Balazs, Kimberly Scearce-Levie, James A. Ernst, Mark S. Dennis, Ryan J. Watts

  Science Translational Medicine01 May 2013 : 183ra57

  The safety of therapeutic bispecific antibodies that use TfR for delivery to the brain can be improved by reducing affinity for TfR and eliminating antibody effector function.

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  Addressing Safety Liabilities of TfR Bispecific Antibodies That Cross the Blood-Brain Barrier

  By Jessica A. Couch, Y. Joy Yu, Yin Zhang, Jacqueline M. Tarrant, Reina N. Fuji, William J. Meilandt, Hilda Solanoy, Raymond K. Tong, Kwame Hoyte, Wilman Luk, Yanmei Lu, Kapil Gadkar, Saileta Prabhu, Benjamin A. Ordonia, Quyen Nguyen, Yuwen Lin, Zhonghua Lin, Mercedesz Balazs, Kimberly Scearce-Levie, James A. Ernst, Mark S. Dennis, Ryan J. Watts

  Science Translational Medicine01 May 2013 : 183ra57

  The safety of therapeutic bispecific antibodies that use TfR for delivery to the brain can be improved by reducing affinity for TfR and eliminating antibody effector function.

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