01 May 2013
Vol 5, Issue 183

About The Cover

Cover image expansion

ONLINE COVER A Migraine Mutation. The terrible pain of a migraine headache, depicted here in an artist’s conception, sometimes originates in the genes. In two families, individuals who carried a mutation in casein kinase Iδ also suffered from migraines; mice with the same mutation show migraine-like brain abnormalities. This kinase, a second messenger–independent enzyme, participates in regulation of the circadian clock, which may—or may not—be the route by which the mutation affects migraines. These finding are discussed in a Research Article by Brennan and colleagues and in an accompanying Focus by Palotie et al. [CREDIT: ZINA DERETSKY/ZINA-STUDIO]