Contents

Contents

• Focus

  • Integrating Physical Sciences Perspectives in Cancer Research

    By Nastaran Z. Kuhn, Larry A. Nagahara

    Science Translational Medicine01 May 2013 : 183fs14 Full AccessRestricted Access

    Cancer research integrated a physical sciences perspective through team science, which fostered communication, trust, joint publication, and open access to data.

    • Abstract
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  • Probing the Brain of Comorbidity

    By Aarno Palotie, Mikko Kallela, Verneri Anttila

    Science Translational Medicine01 May 2013 : 183fs15 Full AccessRestricted Access

    Inherited sleep disorders might provide insights for migraine pathophysiology.

    • Abstract
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• Research Articles

  • Casein Kinase Iδ Mutations in Familial Migraine and Advanced Sleep Phase

    By K. C. Brennan, Emily A. Bates, Robert E. Shapiro, Jekaterina Zyuzin, William C. Hallows, Yong Huang, Hsien-Yang Lee, Christopher R. Jones, Ying-Hui Fu, Andrew C. Charles, Louis J. Ptáček

    Science Translational Medicine01 May 2013 : 183ra56 Full AccessRestricted Access

    Mutations in casein kinase Iδ that are associated with migraine in patients cause changes in enzymatic function, pain behavior, cortical excitability, and astrocyte signaling in mice.

    • Editor's Summary
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  • Addressing Safety Liabilities of TfR Bispecific Antibodies That Cross the Blood-Brain Barrier

    By Jessica A. Couch, Y. Joy Yu, Yin Zhang, Jacqueline M. Tarrant, Reina N. Fuji, William J. Meilandt, Hilda Solanoy, Raymond K. Tong, Kwame Hoyte, Wilman Luk, Yanmei Lu, Kapil Gadkar, Saileta Prabhu, Benjamin A. Ordonia, Quyen Nguyen, Yuwen Lin, Zhonghua Lin, Mercedesz Balazs, Kimberly Scearce-Levie, James A. Ernst, Mark S. Dennis, Ryan J. Watts

    Science Translational Medicine01 May 2013 : 183ra57 Full AccessRestricted Access

    The safety of therapeutic bispecific antibodies that use TfR for delivery to the brain can be improved by reducing affinity for TfR and eliminating antibody effector function.

    • Editor's Summary
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  • Angiotensin-Converting Enzyme–Induced Activation of Local Angiotensin Signaling Is Required for Ascending Aortic Aneurysms in Fibulin-4–Deficient Mice

    By Jianbin Huang, Yoshito Yamashiro, Christina L. Papke, Yuichi Ikeda, Yanling Lin, Miteshkumar Patel, Tadashi Inagami, Victoria P. Le, Jessica E. Wagenseil, Hiromi Yanagisawa

    Science Translational Medicine01 May 2013 : 183ra58 Full AccessRestricted Access

    Up-regulation of angiotensin-converting enzyme in the aortic wall causes aneurysms in fibulin-4–deficient mice, which can be prevented by losartan or captopril.

    • Editor's Summary
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• Editors' Choice

  • Staying Smart on Statins

    By William J. Mack

    Science Translational Medicine01 May 2013 : 183ec72 Full AccessRestricted Access

    Asymptomatic carotid artery stenosis patients given statins have a lower incidence of stroke and cognitive dysfunction after surgery.

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  • Dangerous Liaisons: When Two Wrongs Just Might Make a Right

    By Trudy G. Oliver

    Science Translational Medicine01 May 2013 : 183ec73 Full AccessRestricted Access

    Radioactive bacteria are exploited to treat metastases in a mouse model of pancreatic cancer.

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  • Stimulating the Prefrontal Cortex to Undo Stimulant Addiction

    By Vikaas S. Sohal

    Science Translational Medicine01 May 2013 : 183ec74 Full AccessRestricted Access

    Chronic cocaine exposure may decrease the excitability of prefrontal neurons; acute changes in prefrontal activity alter cocaine-seeking behavior in rats.

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  • I’ll Take a Steak, with Antibiotic on the Side…

    By Amir Tirosh

    Science Translational Medicine01 May 2013 : 183ec75 Full AccessRestricted Access

    Gut bacteria may be the missing link connecting red meat consumption with increased heart disease risk.

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