Contents
Vol 5, Issue 183
Contents
Focus
- Integrating Physical Sciences Perspectives in Cancer Research
Cancer research integrated a physical sciences perspective through team science, which fostered communication, trust, joint publication, and open access to data.
- Probing the Brain of Comorbidity
Inherited sleep disorders might provide insights for migraine pathophysiology.
Research Articles
- Casein Kinase Iδ Mutations in Familial Migraine and Advanced Sleep Phase
Mutations in casein kinase Iδ that are associated with migraine in patients cause changes in enzymatic function, pain behavior, cortical excitability, and astrocyte signaling in mice.
- Addressing Safety Liabilities of TfR Bispecific Antibodies That Cross the Blood-Brain Barrier
The safety of therapeutic bispecific antibodies that use TfR for delivery to the brain can be improved by reducing affinity for TfR and eliminating antibody effector function.
- Angiotensin-Converting Enzyme–Induced Activation of Local Angiotensin Signaling Is Required for Ascending Aortic Aneurysms in Fibulin-4–Deficient Mice
Up-regulation of angiotensin-converting enzyme in the aortic wall causes aneurysms in fibulin-4–deficient mice, which can be prevented by losartan or captopril.
Editors' Choice
- Staying Smart on Statins
Asymptomatic carotid artery stenosis patients given statins have a lower incidence of stroke and cognitive dysfunction after surgery.
- Dangerous Liaisons: When Two Wrongs Just Might Make a Right
Radioactive bacteria are exploited to treat metastases in a mouse model of pancreatic cancer.
- Stimulating the Prefrontal Cortex to Undo Stimulant Addiction
Chronic cocaine exposure may decrease the excitability of prefrontal neurons; acute changes in prefrontal activity alter cocaine-seeking behavior in rats.
- I’ll Take a Steak, with Antibiotic on the Side…
Gut bacteria may be the missing link connecting red meat consumption with increased heart disease risk.