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Research ArticleNEURODEVELOPMENTAL DISORDERS
Rapamycin Prevents Seizures After Depletion of STRADA in a Rare Neurodevelopmental Disorder
- Whitney E. Parker1,
- Ksenia A. Orlova1,
- William H. Parker1,
- Jacqueline F. Birnbaum1,
- Vera P. Krymskaya2,
- Dmitry A. Goncharov2,
- Marianna Baybis1,
- Jelte Helfferich1,3,
- Kei Okochi1,
- Kevin A. Strauss4,5,6 and
- Peter B. Crino1,*
- 1Penn Epilepsy Center and Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
- 2Pulmonary, Allergy and Critical Care Division, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
- 3University of Groningen School of Medicine, Groningen, the Netherlands.
- 4Clinic for Special Children, Strasburg, PA 17579, USA.
- 5Department of Biology, Franklin and Marshall College, Lancaster, PA 17603, USA.
- 6Lancaster General Hospital, Lancaster, PA 17602, USA.
- ↵*Corresponding author. E-mail: peter.crino{at}temple.edu
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Science Translational Medicine 24 Apr 2013:
Vol. 5, Issue 182, pp. 182ra53
DOI: 10.1126/scitranslmed.3005271
Vol. 5, Issue 182, pp. 182ra53
DOI: 10.1126/scitranslmed.3005271
Whitney E. Parker
1Penn Epilepsy Center and Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Ksenia A. Orlova
1Penn Epilepsy Center and Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
William H. Parker
1Penn Epilepsy Center and Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Jacqueline F. Birnbaum
1Penn Epilepsy Center and Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Vera P. Krymskaya
2Pulmonary, Allergy and Critical Care Division, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Dmitry A. Goncharov
2Pulmonary, Allergy and Critical Care Division, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Marianna Baybis
1Penn Epilepsy Center and Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Jelte Helfferich
1Penn Epilepsy Center and Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
3University of Groningen School of Medicine, Groningen, the Netherlands.
Kei Okochi
1Penn Epilepsy Center and Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Kevin A. Strauss
4Clinic for Special Children, Strasburg, PA 17579, USA.
5Department of Biology, Franklin and Marshall College, Lancaster, PA 17603, USA.
6Lancaster General Hospital, Lancaster, PA 17602, USA.
Peter B. Crino
1Penn Epilepsy Center and Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
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