Rapamycin Prevents Seizures After Depletion of STRADA in a Rare Neurodevelopmental Disorder

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  Rapamycin Prevents Seizures After Depletion of STRADA in a Rare Neurodevelopmental Disorder

  By Whitney E. Parker, Ksenia A. Orlova, William H. Parker, Jacqueline F. Birnbaum, Vera P. Krymskaya, Dmitry A. Goncharov, Marianna Baybis, Jelte Helfferich, Kei Okochi, Kevin A. Strauss, Peter B. Crino

  Science Translational Medicine24 Apr 2013 : 182ra53

  Blocking mTORC1 rescues the neural progenitor cell migratory defect caused by depletion of the STRADA pseudokinase and reduces seizures in patients with a rare neurodevelopmental disorder.

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  Rapamycin Prevents Seizures After Depletion of STRADA in a Rare Neurodevelopmental Disorder

  By Whitney E. Parker, Ksenia A. Orlova, William H. Parker, Jacqueline F. Birnbaum, Vera P. Krymskaya, Dmitry A. Goncharov, Marianna Baybis, Jelte Helfferich, Kei Okochi, Kevin A. Strauss, Peter B. Crino

  Science Translational Medicine24 Apr 2013 : 182ra53

  Blocking mTORC1 rescues the neural progenitor cell migratory defect caused by depletion of the STRADA pseudokinase and reduces seizures in patients with a rare neurodevelopmental disorder.

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