ReportsCROWDSOURCING
Systematic Analysis of Challenge-Driven Improvements in Molecular Prognostic Models for Breast Cancer
- Adam A. Margolin1,*,†,
- Erhan Bilal2,†,
- Erich Huang1,3,4,†,
- Thea C. Norman1,
- Lars Ottestad5,
- Brigham H. Mecham1,6,
- Ben Sauerwine7,
- Michael R. Kellen1,
- Lara M. Mangravite1,
- Matthew D. Furia1,8,
- Hans Kristian Moen Vollan5,9,10,11,
- Oscar M. Rueda11,
- Justin Guinney1,
- Nicole A. Deflaux1,
- Bruce Hoff1,
- Xavier Schildwachter1,
- Hege G. Russnes9,10,12,
- Daehoon Park13,
- Veronica O. Vang9,10,
- Tyler Pirtle7,
- Lamia Youseff7,
- Craig Citro7,
- Christina Curtis14,
- Vessela N. Kristensen9,10,15,
- Joseph Hellerstein7,
- Stephen H. Friend1,*,
- Gustavo Stolovitzky2,
- Samuel Aparicio16,17,18,†,
- Carlos Caldas11,19,20,† and
- Anne-Lise Børresen-Dale9,10,†
- 1Sage Bionetworks, 1100 Fairview Avenue North, MS: M1-C108, Seattle, WA 98109, USA.
- 2Functional Genomics and Systems Biology, IBM Computational Biology Center, P. O. Box 218, Yorktown Heights, NY 10598, USA.
- 3Institute for Genome Sciences & Policy, Duke University, Durham, NC 27708, USA.
- 4Department of Surgery, Duke University School of Medicine, Durham, NC 27710, USA.
- 5Department of Oncology, Division of Cancer, Surgery and Transplantation, Oslo University Hospital, 0450 Oslo, Norway.
- 6Trialomics, LLC, Seattle, WA 98103, USA.
- 7Google Inc., 651 North 34th Street, Seattle, WA 98103, USA.
- 8Genomics Institute of the Novartis Research Foundation, San Diego, CA 92121, USA.
- 9Department of Genetics, Institute for Cancer Research, Oslo University Hospital, The Norwegian Radium Hospital, Montebello, 0310 Oslo, Norway.
- 10K.G. Jebsen Centre for Breast Cancer Research, Institute for Clinical Medicine, Faculty of Medicine, University of Oslo, 0313 Oslo, Norway.
- 11Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK.
- 12Department of Pathology, Oslo University Hospital, 0450 Oslo, Norway.
- 13Department of Pathology, Drammen Hospital, Vestre Viken HF, 3004 Drammen, Norway.
- 14Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
- 15Department of Clinical Molecular Oncology, Division of Medicine, Akershus University Hospital, 1478 Ahus, Norway.
- 16Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia V5Z 1L3, Canada.
- 17Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada.
- 18Genome Sciences Centre, BC Cancer Agency, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada.
- 19Cambridge Breast Unit, Addenbrooke’s Hospital, Cambridge University Hospital NHS Foundation Trust and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 2QQ, UK.
- 20Cambridge Experimental Cancer Medicine Centre, Cambridge CB2 0RE, UK.
- ↵*Corresponding author. E-mail: margolin{at}sagebase.org (A.A.M.); friend{at}sagebase.org (S.H.F.)
-
↵† These authors contributed equally to this work.
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Science Translational Medicine 17 Apr 2013:
Vol. 5, Issue 181, pp. 181re1
DOI: 10.1126/scitranslmed.3006112
Vol. 5, Issue 181, pp. 181re1
DOI: 10.1126/scitranslmed.3006112
Adam A. Margolin
1Sage Bionetworks, 1100 Fairview Avenue North, MS: M1-C108, Seattle, WA 98109, USA.
Erhan Bilal
2Functional Genomics and Systems Biology, IBM Computational Biology Center, P. O. Box 218, Yorktown Heights, NY 10598, USA.
Erich Huang
1Sage Bionetworks, 1100 Fairview Avenue North, MS: M1-C108, Seattle, WA 98109, USA.
3Institute for Genome Sciences & Policy, Duke University, Durham, NC 27708, USA.
4Department of Surgery, Duke University School of Medicine, Durham, NC 27710, USA.
Thea C. Norman
1Sage Bionetworks, 1100 Fairview Avenue North, MS: M1-C108, Seattle, WA 98109, USA.
Lars Ottestad
5Department of Oncology, Division of Cancer, Surgery and Transplantation, Oslo University Hospital, 0450 Oslo, Norway.
Brigham H. Mecham
1Sage Bionetworks, 1100 Fairview Avenue North, MS: M1-C108, Seattle, WA 98109, USA.
6Trialomics, LLC, Seattle, WA 98103, USA.
Ben Sauerwine
7Google Inc., 651 North 34th Street, Seattle, WA 98103, USA.
Michael R. Kellen
1Sage Bionetworks, 1100 Fairview Avenue North, MS: M1-C108, Seattle, WA 98109, USA.
Lara M. Mangravite
1Sage Bionetworks, 1100 Fairview Avenue North, MS: M1-C108, Seattle, WA 98109, USA.
Matthew D. Furia
1Sage Bionetworks, 1100 Fairview Avenue North, MS: M1-C108, Seattle, WA 98109, USA.
8Genomics Institute of the Novartis Research Foundation, San Diego, CA 92121, USA.
Hans Kristian Moen Vollan
5Department of Oncology, Division of Cancer, Surgery and Transplantation, Oslo University Hospital, 0450 Oslo, Norway.
9Department of Genetics, Institute for Cancer Research, Oslo University Hospital, The Norwegian Radium Hospital, Montebello, 0310 Oslo, Norway.
10K.G. Jebsen Centre for Breast Cancer Research, Institute for Clinical Medicine, Faculty of Medicine, University of Oslo, 0313 Oslo, Norway.
11Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK.
Oscar M. Rueda
11Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK.
Justin Guinney
1Sage Bionetworks, 1100 Fairview Avenue North, MS: M1-C108, Seattle, WA 98109, USA.
Nicole A. Deflaux
1Sage Bionetworks, 1100 Fairview Avenue North, MS: M1-C108, Seattle, WA 98109, USA.
Bruce Hoff
1Sage Bionetworks, 1100 Fairview Avenue North, MS: M1-C108, Seattle, WA 98109, USA.
Xavier Schildwachter
1Sage Bionetworks, 1100 Fairview Avenue North, MS: M1-C108, Seattle, WA 98109, USA.
Hege G. Russnes
9Department of Genetics, Institute for Cancer Research, Oslo University Hospital, The Norwegian Radium Hospital, Montebello, 0310 Oslo, Norway.
10K.G. Jebsen Centre for Breast Cancer Research, Institute for Clinical Medicine, Faculty of Medicine, University of Oslo, 0313 Oslo, Norway.
12Department of Pathology, Oslo University Hospital, 0450 Oslo, Norway.
Daehoon Park
13Department of Pathology, Drammen Hospital, Vestre Viken HF, 3004 Drammen, Norway.
Veronica O. Vang
9Department of Genetics, Institute for Cancer Research, Oslo University Hospital, The Norwegian Radium Hospital, Montebello, 0310 Oslo, Norway.
10K.G. Jebsen Centre for Breast Cancer Research, Institute for Clinical Medicine, Faculty of Medicine, University of Oslo, 0313 Oslo, Norway.
Tyler Pirtle
7Google Inc., 651 North 34th Street, Seattle, WA 98103, USA.
Lamia Youseff
7Google Inc., 651 North 34th Street, Seattle, WA 98103, USA.
Craig Citro
7Google Inc., 651 North 34th Street, Seattle, WA 98103, USA.
Christina Curtis
14Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Vessela N. Kristensen
9Department of Genetics, Institute for Cancer Research, Oslo University Hospital, The Norwegian Radium Hospital, Montebello, 0310 Oslo, Norway.
10K.G. Jebsen Centre for Breast Cancer Research, Institute for Clinical Medicine, Faculty of Medicine, University of Oslo, 0313 Oslo, Norway.
15Department of Clinical Molecular Oncology, Division of Medicine, Akershus University Hospital, 1478 Ahus, Norway.
Joseph Hellerstein
7Google Inc., 651 North 34th Street, Seattle, WA 98103, USA.
Stephen H. Friend
1Sage Bionetworks, 1100 Fairview Avenue North, MS: M1-C108, Seattle, WA 98109, USA.
Gustavo Stolovitzky
2Functional Genomics and Systems Biology, IBM Computational Biology Center, P. O. Box 218, Yorktown Heights, NY 10598, USA.
Samuel Aparicio
16Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia V5Z 1L3, Canada.
17Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada.
18Genome Sciences Centre, BC Cancer Agency, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada.
Carlos Caldas
11Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK.
19Cambridge Breast Unit, Addenbrooke’s Hospital, Cambridge University Hospital NHS Foundation Trust and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 2QQ, UK.
20Cambridge Experimental Cancer Medicine Centre, Cambridge CB2 0RE, UK.
Anne-Lise Børresen-Dale
9Department of Genetics, Institute for Cancer Research, Oslo University Hospital, The Norwegian Radium Hospital, Montebello, 0310 Oslo, Norway.
10K.G. Jebsen Centre for Breast Cancer Research, Institute for Clinical Medicine, Faculty of Medicine, University of Oslo, 0313 Oslo, Norway.
