Research ArticleAcute Myeloid Leukemia

A Pyrrolo-Pyrimidine Derivative Targets Human Primary AML Stem Cells in Vivo

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Science Translational Medicine  17 Apr 2013:
Vol. 5, Issue 181, pp. 181ra52
DOI: 10.1126/scitranslmed.3004387

Article Information

vol. 5 no. 181 181ra52

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication May 29, 2012
  • Accepted for publication February 19, 2013
  • .

Author Information

  1. Yoriko Saito1,
  2. Hitomi Yuki2,
  3. Mitsuo Kuratani2,
  4. Yoshinobu Hashizume3,
  5. Shinsuke Takagi1,4,
  6. Teruki Honma2,
  7. Akiko Tanaka2,
  8. Mikako Shirouzu2,
  9. Junko Mikuni2,
  10. Noriko Handa2,
  11. Ikuko Ogahara1,
  12. Akiko Sone1,
  13. Yuho Najima1,
  14. Yuri Tomabechi2,
  15. Motoaki Wakiyama2,
  16. Naoyuki Uchida4,
  17. Mariko Tomizawa-Murasawa1,
  18. Akiko Kaneko1,
  19. Satoshi Tanaka5,
  20. Nahoko Suzuki1,
  21. Hiroshi Kajita1,
  22. Yuki Aoki1,
  23. Osamu Ohara6,
  24. Leonard D. Shultz7,
  25. Takehiro Fukami8,
  26. Toshio Goto8,
  27. Shuichi Taniguchi4,
  28. Shigeyuki Yokoyama2 and
  29. Fumihiko Ishikawa1,*
  1. 1Laboratory for Human Disease Models, RIKEN Research Center for Allergy and Immunology, Yokohama, Kanagawa 230-0045, Japan.
  2. 2RIKEN Systems and Structural Biology Center, Yokohama, Kanagawa 230-0045, Japan.
  3. 3Drug Discovery Chemistry Platform Unit, RIKEN Center for Molecular Imaging Science, Wako, Saitama 351-0198, Japan.
  4. 4Department of Hematology, Toranomon Hospital, Tokyo 105-8470, Japan.
  5. 5Nippon Becton Dickinson Company, Tokyo 107-0052, Japan.
  6. 6Laboratory for Immunogenomics, RIKEN Research Center for Allergy and Immunology, Yokohama, Kanagawa 230-0045, Japan.
  7. 7The Jackson Laboratory, Bar Harbor, ME 04609, USA.
  8. 8RIKEN Program for Drug Discovery and Medical Technology Platforms, Yokohama, Kanagawa 230-0045, Japan.
  1. *Corresponding author. E-mail: f_ishika{at}rcai.riken.jp

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