Contents
Vol 5, Issue 180
Contents
Focus
- Microbes and the Malnourished Child
New research implicates a dysfunctional gut microbiome in the etiology of severe childhood malnutrition and confirms a role for antibiotics in its treatment.
- For Whom the Bell Tolls: Isoniazid Preventive Therapy and Tuberculosis Drug Resistance
The expected increase in drug-resistant tuberculosis due to large-scale preventive treatment in people living with HIV calls for reconsidering the “double use” of isoniazid for prophylaxis and curative treatment.
Research Articles
- The Identification and Characterization of Breast Cancer CTCs Competent for Brain Metastasis
EpCAM− CTCs isolated from breast cancer patients express markers needed to promote brain metastasis.
- Community-Wide Isoniazid Preventive Therapy Drives Drug-Resistant Tuberculosis: A Model-Based Analysis
Community-wide isoniazid preventive therapy may lead to long-term rises in resistance at the population level.
Editors' Choice
- Association Between Telomere Length and Disease—More Evidence
A genome-wide meta-analysis supports a causal association between telomere length and coronary artery disease.
- Fixing Dendritic Spines in Fragile X
Inhibition of PAK, a protein that regulates the actin cytoskeleton, rescues the dendritic spine defect and behavioral abnormalities in a mouse model of fragile X syndrome.
- In Search of a (Functional) Cure
HIV-infected adults who are able to control viral replication after therapy have small latent reservoirs in long-living cells.
- A Liquid Solution for Solid Tumors
Circulating DNA is a superior predictor of tumor response to chemotherapy and survival.
- Offering Guidance for Translation
FDA recently released a draft-guidance on the preclinical assessment of investigational cellular and gene therapy products.
