Contents
Vol 5, Issue 179
Contents
Perspective
- Cell-Based Therapeutics: The Next Pillar of Medicine
Biomedicine sits on the cusp of a new revolution: the use of microbial and human cells as versatile therapeutic engines.
Research Articles
- Amyloid Fibrils Composed of Hexameric Peptides Attenuate Neuroinflammation
Amyloid fibrils may provide anti-inflammatory benefit in MS and other neuroinflammatory disorders.
- Low-Dose Interleukin-2 Therapy Restores Regulatory T Cell Homeostasis in Patients with Chronic Graft-Versus-Host Disease
Regulatory T cell homeostasis is restored in patients with chronic graft-versus-host disease who receive low-dose interleukin-2 therapy.
- Orexin Receptor Antagonists Differ from Standard Sleep Drugs by Promoting Sleep at Doses That Do Not Disrupt Cognition
Selective orexin receptor antagonism promotes sleep at doses lower than those that impair attention and memory in contrast to the GABA receptor–positive allosteric modulators currently in use.
- Inertial Focusing for Tumor Antigen–Dependent and –Independent Sorting of Rare Circulating Tumor Cells
A multistage microfluidic chip is capable of sorting rare EpCAM+ and EpCAM− CTCs from cancer patients’ whole blood.
Editors' Choice
- Skin Substitutes: Already Done, or Just the Beginning?
Laser-assisted bioprinting can create a cellularized skin substitute to heal wounds.
- The Gut Microbiome and Malnutrition
A new study shows that a dysfunctional gut microbiome may contribute to a form of severe acute malnutrition called kwashiorkor.
- Taking the Road Less Traveled: RAS Meets PI3K/PDK1
PI3K is a critical and druggable downstream effector of RAS signaling in pancreatic cancer.
- Making Sense of Missense Mutations
Genetic variation that is deleterious is on average younger than neutral variation.
- Accessing the Inaccessible Genome
Families with a rare kidney disease have a single-base frameshift mutation within a MUC1 repeat region not found with whole-genome sequencing.
Letters
- Comment on “Time to Integrate Clinical and Research Informatics”
The same code standards should be used in both research and clinical care to facilitate data integration across domains.
- Author Response to Comment on “Time to Integrate Clinical and Research Informatics”
Lack of structured clinical data limits research potential of EHRs, and efforts to establish clinical data standards should be a priority.
Podcast
- Science Translational Medicine Podcast: 3 April 2013
In this podcast, Jason Uslaner discusses the discovery of a new class of sleep inducing agents with fewer side effects than existing sedatives.
Erratum
