CD19-Targeted T Cells Rapidly Induce Molecular Remissions in Adults with Chemotherapy-Refractory Acute Lymphoblastic Leukemia

Renier J. Brentjens; Marco L. Davila; Isabelle Riviere; Jae Park; Xiuyan Wang; Lindsay G. Cowell; Shirley Bartido; Jolanta Stefanski; Clare Taylor; Malgorzata Olszewska; Oriana Borquez-Ojeda; Jinrong Qu; Teresa Wasielewska; Qing He; Yvette Bernal; Ivelise V. Rijo; Cyrus Hedvat; Rachel Kobos; Kevin Curran; Peter Steinherz; Joseph Jurcic; Todd Rosenblat; Peter Maslak; Mark Frattini; Michel Sadelain

doi:10.1126/scitranslmed.3005930

Research ArticleCancer Immunotherapy

CD19-Targeted T Cells Rapidly Induce Molecular Remissions in Adults with Chemotherapy-Refractory Acute Lymphoblastic Leukemia

Renier J. Brentjens¹,²,³,*,†,
Marco L. Davila¹,†,
Isabelle Riviere¹,²,³,⁴,†,
Jae Park¹,
Xiuyan Wang³,⁴,
Lindsay G. Cowell⁵,
Shirley Bartido⁴,
Jolanta Stefanski⁴,
Clare Taylor⁴,
Malgorzata Olszewska⁴,
Oriana Borquez-Ojeda⁴,
Jinrong Qu⁴,
Teresa Wasielewska⁴,
Qing He⁴,
Yvette Bernal¹,
Ivelise V. Rijo⁶,
Cyrus Hedvat⁶,
Rachel Kobos⁷,
Kevin Curran⁷,
Peter Steinherz⁷,
Joseph Jurcic¹,
Todd Rosenblat¹,
Peter Maslak¹,
Mark Frattini¹ and
Michel Sadelain¹,²,³,*

¹Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.
²Center for Cell Engineering, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.
³Molecular Pharmacology and Chemistry Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.
⁴Cell Therapy and Cell Engineering Facility, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.
⁵Department of Clinical Sciences, UT Southwestern, Dallas, TX 75390, USA.
⁶Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.
⁷Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

↵*Corresponding author. E-mail: brentjer{at}mskcc.org (R.B.); m-sadelain{at}ski.mskcc.org (M.S.)

↵† These authors contributed equally to this work.

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Science Translational Medicine 20 Mar 2013:
Vol. 5, Issue 177, pp. 177ra38
DOI: 10.1126/scitranslmed.3005930

Renier J. Brentjens

Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.Center for Cell Engineering, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.Molecular Pharmacology and Chemistry Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

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For correspondence: brentjer@mskcc.org m-sadelain@ski.mskcc.org

Marco L. Davila

Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

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Isabelle Riviere

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Jae Park

Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

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Xiuyan Wang

Molecular Pharmacology and Chemistry Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.Cell Therapy and Cell Engineering Facility, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

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Lindsay G. Cowell

Department of Clinical Sciences, UT Southwestern, Dallas, TX 75390, USA.

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Shirley Bartido