Research ArticleCancer Immunotherapy

CD19-Targeted T Cells Rapidly Induce Molecular Remissions in Adults with Chemotherapy-Refractory Acute Lymphoblastic Leukemia

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Science Translational Medicine  20 Mar 2013:
Vol. 5, Issue 177, pp. 177ra38
DOI: 10.1126/scitranslmed.3005930

Article Information

vol. 5 no. 177 177ra38

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication February 13, 2013
  • Accepted for publication March 8, 2013
  • .

Author Information

  1. Renier J. Brentjens1,2,3,*,,
  2. Marco L. Davila1,,
  3. Isabelle Riviere1,2,3,4,,
  4. Jae Park1,
  5. Xiuyan Wang3,4,
  6. Lindsay G. Cowell5,
  7. Shirley Bartido4,
  8. Jolanta Stefanski4,
  9. Clare Taylor4,
  10. Malgorzata Olszewska4,
  11. Oriana Borquez-Ojeda4,
  12. Jinrong Qu4,
  13. Teresa Wasielewska4,
  14. Qing He4,
  15. Yvette Bernal1,
  16. Ivelise V. Rijo6,
  17. Cyrus Hedvat6,
  18. Rachel Kobos7,
  19. Kevin Curran7,
  20. Peter Steinherz7,
  21. Joseph Jurcic1,
  22. Todd Rosenblat1,
  23. Peter Maslak1,
  24. Mark Frattini1 and
  25. Michel Sadelain1,2,3,*
  1. 1Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.
  2. 2Center for Cell Engineering, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.
  3. 3Molecular Pharmacology and Chemistry Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.
  4. 4Cell Therapy and Cell Engineering Facility, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.
  5. 5Department of Clinical Sciences, UT Southwestern, Dallas, TX 75390, USA.
  6. 6Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.
  7. 7Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.
  1. *Corresponding author. E-mail: brentjer{at}mskcc.org (R.B.); m-sadelain{at}ski.mskcc.org (M.S.)
  • These authors contributed equally to this work.

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