Contents

Contents

• Focus

  • Advancing Regenerative Medicine the Translational Way

    By Edwin M. Horwitz

    Science Translational Medicine20 Mar 2013 : 177fs9 Full AccessRestricted Access

    A subset of circulating T cells can impair bone regeneration and fracture healing.

    • Abstract
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• Perspectives

  • Optogenetics and Translational Medicine

    By Brian Y. Chow, Edward S. Boyden

    Science Translational Medicine20 Mar 2013 : 177ps5 Full AccessRestricted Access

    Optogenetics has proven useful for understanding basic neurobiology and may next serve as a therapeutic modality in the clinic.

    • Abstract
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  • From Optogenetic Technologies to Neuromodulation Therapies

    By Justin C. Williams, Timothy Denison

    Science Translational Medicine20 Mar 2013 : 177ps6 Full AccessRestricted Access

    Translating optogenetic technologies into the clinic will encounter a number of technical, practical, and regulatory hurdles.

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• Research Articles

  • Intracellular Aggregation of Multimodal Silica Nanoparticles for Ultrasound-Guided Stem Cell Implantation

    By Jesse V. Jokerst, Christine Khademi, Sanjiv S. Gambhir

    Science Translational Medicine20 Mar 2013 : 177ra35 Full AccessRestricted Access

    Silica nanoparticles enable multimodel imaging of stem cell implantation into the mouse heart.

    • Editor's Summary
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  • Terminally Differentiated CD8⁺ T Cells Negatively Affect Bone Regeneration in Humans

    By Simon Reinke, Sven Geissler, William R. Taylor, Katharina Schmidt-Bleek, Kerstin Juelke, Verena Schwachmeyer, Michael Dahne, Tony Hartwig, Levent Akyüz, Christian Meisel, Nadine Unterwalder, Navrag B. Singh, Petra Reinke, Norbert P. Haas, Hans-Dieter Volk, Georg N. Duda

    Science Translational Medicine20 Mar 2013 : 177ra36 Full AccessRestricted Access

    A subset of T cells inhibits bone regeneration in humans.

    • Editor's Summary
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  • Quinolone-3-Diarylethers: A New Class of Antimalarial Drug

    By Aaron Nilsen, Alexis N. LaCrue, Karen L. White, Isaac P. Forquer, R. Matthew Cross, Jutta Marfurt, Michael W. Mather, Michael J. Delves, David M. Shackleford, Fabian E. Saenz, Joanne M. Morrisey, Jessica Steuten, Tina Mutka, Yuexin Li, Grennady Wirjanata, Eileen Ryan, Sandra Duffy, Jane Xu Kelly, Boni F. Sebayang, Anne-Marie Zeeman, Rintis Noviyanti, Robert E. Sinden, Clemens H. M. Kocken, Ric N. Price, Vicky M. Avery, Iñigo Angulo-Barturen, María Belén Jiménez-Díaz, Santiago Ferrer, Esperanza Herreros, Laura M. Sanz, Francisco-Javier Gamo, Ian Bathurst, Jeremy N. Burrows, Peter Siegl, R. Kiplin Guy, Rolf W. Winter, Akhil B. Vaidya, Susan A. Charman, Dennis E. Kyle, Roman Manetsch, Michael K. Riscoe

    Science Translational Medicine20 Mar 2013 : 177ra37 Full AccessRestricted Access

    ELQ-300, an investigational drug for treating and preventing malaria, shows potent transmission-blocking activity in rodent models of malaria.

    • Editor's Summary
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  • CD19-Targeted T Cells Rapidly Induce Molecular Remissions in Adults with Chemotherapy-Refractory Acute Lymphoblastic Leukemia

    By Renier J. Brentjens, Marco L. Davila, Isabelle Riviere, Jae Park, Xiuyan Wang, Lindsay G. Cowell, Shirley Bartido, Jolanta Stefanski, Clare Taylor, Malgorzata Olszewska, Oriana Borquez-Ojeda, Jinrong Qu, Teresa Wasielewska, Qing He, Yvette Bernal, Ivelise V. Rijo, Cyrus Hedvat, Rachel Kobos, Kevin Curran, Peter Steinherz, Joseph Jurcic, Todd Rosenblat, Peter Maslak, Mark Frattini, Michel Sadelain

    Science Translational Medicine20 Mar 2013 : 177ra38 Full AccessRestricted Access

    Five adults with chemotherapy-refractory B-ALL were induced into molecular remissions after treatment with CD19 CAR-targeted T cells.

    • Editor's Summary
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• Editors' Choice

  • A Stroke of Insight

    By William J. Mack

    Science Translational Medicine20 Mar 2013 : 177ec46 Full AccessRestricted Access

    A combination of intravenous t-PA and endovascular therapy is not more effective than t-PA alone for treating patients with moderate-to-severe acute ischemic stroke.

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  • Ovarian Stem Cells Find Their Niche

    By Trudy G. Oliver

    Science Translational Medicine20 Mar 2013 : 177ec47 Full AccessRestricted Access

    A population of stem cells in the mouse hilum are prone to epithelial ovarian cancer.

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  • Neurons Themselves May Shy Away from Normal Interactions in Autism

    By Vikaas Sohal

    Science Translational Medicine20 Mar 2013 : 177ec48 Full AccessRestricted Access

    This study suggests that in some forms of autism, neurons may abnormally retract their dendrites in response to stimulation.

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  • High RANKs for Diabetes and Osteoporosis

    By Amir Tirosh

    Science Translational Medicine20 Mar 2013 : 177ec49 Full AccessRestricted Access

    Blockade of RANKL signaling, a known approach for treating osteoporosis, may also improve liver insulin resistance and diabetes.

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