20 March 2013
Vol 5, Issue 177
  • Contents

    • Focus

    • Perspectives

    • Research Articles

      • Terminally Differentiated CD8+ T Cells Negatively Affect Bone Regeneration in Humans

        A subset of T cells inhibits bone regeneration in humans.

      • Quinolone-3-Diarylethers: A New Class of Antimalarial Drug

        ELQ-300, an investigational drug for treating and preventing malaria, shows potent transmission-blocking activity in rodent models of malaria.

      • CD19-Targeted T Cells Rapidly Induce Molecular Remissions in Adults with Chemotherapy-Refractory Acute Lymphoblastic Leukemia

        Five adults with chemotherapy-refractory B-ALL were induced into molecular remissions after treatment with CD19 CAR-targeted T cells.

    • Editors' Choice

      • A Stroke of Insight

        A combination of intravenous t-PA and endovascular therapy is not more effective than t-PA alone for treating patients with moderate-to-severe acute ischemic stroke.

      • Ovarian Stem Cells Find Their Niche

        A population of stem cells in the mouse hilum are prone to epithelial ovarian cancer.

      • High RANKs for Diabetes and Osteoporosis

        Blockade of RANKL signaling, a known approach for treating osteoporosis, may also improve liver insulin resistance and diabetes.

About The Cover

Cover image expansion

ONLINE COVER A Guiding Light. For most, the thought of controlling human behavior and treating neurological diseases with light seems like science fiction. But a maturing field, called optogenetics, works to combine gene therapy with light-based cues to turn such fiction into reality in the clinic. As shown on this week’s futuristic cover, an array of thin, microsized silicon waveguides has been designed to deliver light to multiple targets in three-dimensional space within the brain. Currently being tested in animals, this optogenetic technology could soon find its way into humans. Perspectives in this issue from Chow and Boyden and from Williams and Denison highlight the scientific, practical, and regulatory hurdles that need to be cleared before translation is possible. [CREDIT: C. BICKEL/SCIENCE TRANSLATIONAL MEDICINE.]