Contents
Vol 5, Issue 177
Contents
Focus
- Advancing Regenerative Medicine the Translational Way
A subset of circulating T cells can impair bone regeneration and fracture healing.
Perspectives
- Optogenetics and Translational Medicine
Optogenetics has proven useful for understanding basic neurobiology and may next serve as a therapeutic modality in the clinic.
- From Optogenetic Technologies to Neuromodulation Therapies
Translating optogenetic technologies into the clinic will encounter a number of technical, practical, and regulatory hurdles.
Research Articles
- Intracellular Aggregation of Multimodal Silica Nanoparticles for Ultrasound-Guided Stem Cell Implantation
Silica nanoparticles enable multimodel imaging of stem cell implantation into the mouse heart.
- Terminally Differentiated CD8+ T Cells Negatively Affect Bone Regeneration in Humans
A subset of T cells inhibits bone regeneration in humans.
- Quinolone-3-Diarylethers: A New Class of Antimalarial Drug
ELQ-300, an investigational drug for treating and preventing malaria, shows potent transmission-blocking activity in rodent models of malaria.
- CD19-Targeted T Cells Rapidly Induce Molecular Remissions in Adults with Chemotherapy-Refractory Acute Lymphoblastic Leukemia
Five adults with chemotherapy-refractory B-ALL were induced into molecular remissions after treatment with CD19 CAR-targeted T cells.
Editors' Choice
- A Stroke of Insight
A combination of intravenous t-PA and endovascular therapy is not more effective than t-PA alone for treating patients with moderate-to-severe acute ischemic stroke.
- Ovarian Stem Cells Find Their Niche
A population of stem cells in the mouse hilum are prone to epithelial ovarian cancer.
- Neurons Themselves May Shy Away from Normal Interactions in Autism
This study suggests that in some forms of autism, neurons may abnormally retract their dendrites in response to stimulation.
- High RANKs for Diabetes and Osteoporosis
Blockade of RANKL signaling, a known approach for treating osteoporosis, may also improve liver insulin resistance and diabetes.