Contents
Vol 5, Issue 176
Contents
Commentary
- Regulatory and Reimbursement Innovation
Coverage with evidence development and parallel review for molecular diagnostics aid regulation and reimbursement.
Perspective
- Acellular Biomaterials: An Evolving Alternative to Cell-Based Therapies
Acellular biomaterials are emerging as viable treatment options for patients with damaged tissues.
Research Articles
- Induction of ICOS+CXCR3+CXCR5+ TH Cells Correlates with Antibody Responses to Influenza Vaccination
A T cell subset that emerges in blood after seasonal influenza vaccinations correlates with the development of protective antibody responses.
- Targeting the Intracellular WT1 Oncogene Product with a Therapeutic Human Antibody
A therapeutic monoclonal antibody specific for the intracellular oncoprotein Wilms tumor 1 treats human leukemias in mice.
- Proteoglycan 4 Expression Protects Against the Development of Osteoarthritis
Proteoglycan 4 protects from age-related and posttraumatic osteoarthritis development.
Editors' Choice
- A Jagged Edge to Cancer Chemoresistance
Endothelial cells stimulate the cancer stem cell phenotype in human colorectal cancer cells by cleaving a Notch ligand.
- Gut Reaction: Microbiome Provides a Clue to Gender Bias in Autoimmunity
The gut microbiome may regulate hormone levels, thus contributing to gender bias in autoimmunity.
- Lights of Hope in the Treatment of Epilepsy
Optogenetic control of neuronal excitability in the thalamus can interrupt seizures in a rat model of epilepsy.
- Heart Versus Lungs in Hypertension Tug-of-War
The beneficial effects of endothelin receptor antagonists on the lung are partially negated by its adverse effects on the heart in pulmonary arterial hypertension.