Contents

Contents

• Commentary

  • Regulatory and Reimbursement Innovation

    By Rachel A. Lindor, Scott J. Allocco, Lee Cheatham, Denis A. Cortese, Ralph F. Hall, William J. Mangold, Jr., Vincent Pizziconi, George Poste, Bruce Quinn, Mollie Roth, Michael J. Saks, E. Robert Wassman, Raymond L. Woosley, Gary E. Marchant

    Science Translational Medicine13 Mar 2013 : 176cm3 Full AccessRestricted Access

    Coverage with evidence development and parallel review for molecular diagnostics aid regulation and reimbursement.

    • Abstract
    • Full Text
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• Perspective

  • Acellular Biomaterials: An Evolving Alternative to Cell-Based Therapies

    By Jason A. Burdick, Robert L. Mauck, Joseph H. Gorman III, Robert C. Gorman

    Science Translational Medicine13 Mar 2013 : 176ps4 Full AccessRestricted Access

    Acellular biomaterials are emerging as viable treatment options for patients with damaged tissues.

    • Abstract
    • Full Text
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• Research Articles

  • Induction of ICOS⁺CXCR3⁺CXCR5⁺ T_H Cells Correlates with Antibody Responses to Influenza Vaccination

    By Salah-Eddine Bentebibel, Santiago Lopez, Gerlinde Obermoser, Nathalie Schmitt, Cynthia Mueller, Carson Harrod, Emilio Flano, Asuncion Mejias, Randy A. Albrecht, Derek Blankenship, Hui Xu, Virginia Pascual, Jacques Banchereau, Adolfo Garcia-Sastre, Anna Karolina Palucka, Octavio Ramilo, Hideki Ueno

    Science Translational Medicine13 Mar 2013 : 176ra32 Full AccessRestricted Access

    A T cell subset that emerges in blood after seasonal influenza vaccinations correlates with the development of protective antibody responses.

    • Editor's Summary
    • Abstract
    • Full Text
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  • Targeting the Intracellular WT1 Oncogene Product with a Therapeutic Human Antibody

    By Tao Dao, Su Yan, Nicholas Veomett, Dmitry Pankov, Liang Zhou, Tatyana Korontsvit, Andrew Scott, Joseph Whitten, Peter Maslak, Emily Casey, Taochao Tan, Hong Liu, Victoria Zakhaleva, Michael Curcio, Ekaterina Doubrovina, Richard J. O’Reilly, Cheng Liu, David A. Scheinberg

    Science Translational Medicine13 Mar 2013 : 176ra33 Full AccessRestricted Access

    A therapeutic monoclonal antibody specific for the intracellular oncoprotein Wilms tumor 1 treats human leukemias in mice.

    • Editor's Summary
    • Abstract
    • Full Text
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  • Proteoglycan 4 Expression Protects Against the Development of Osteoarthritis

    By Merry Z. C. Ruan, Ayelet Erez, Kilian Guse, Brian Dawson, Terry Bertin, Yuqing Chen, Ming-Ming Jiang, Jason Yustein, Francis Gannon, Brendan H. L. Lee

    Science Translational Medicine13 Mar 2013 : 176ra34 Full AccessRestricted Access

    Proteoglycan 4 protects from age-related and posttraumatic osteoarthritis development.

    • Editor's Summary
    • Abstract
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• Editors' Choice

  • A Jagged Edge to Cancer Chemoresistance

    By Cyrus M. Ghajar

    Science Translational Medicine13 Mar 2013 : 176ec42 Full AccessRestricted Access

    Endothelial cells stimulate the cancer stem cell phenotype in human colorectal cancer cells by cleaving a Notch ligand.

    • Full Text

  • Gut Reaction: Microbiome Provides a Clue to Gender Bias in Autoimmunity

    By Margaret K. Callahan

    Science Translational Medicine13 Mar 2013 : 176ec43 Full AccessRestricted Access

    The gut microbiome may regulate hormone levels, thus contributing to gender bias in autoimmunity.

    • Full Text

  • Lights of Hope in the Treatment of Epilepsy

    By Tore Eid

    Science Translational Medicine13 Mar 2013 : 176ec44 Full AccessRestricted Access

    Optogenetic control of neuronal excitability in the thalamus can interrupt seizures in a rat model of epilepsy.

    • Full Text

  • Heart Versus Lungs in Hypertension Tug-of-War

    By Adriano R. Tonelli

    Science Translational Medicine13 Mar 2013 : 176ec45 Full AccessRestricted Access

    The beneficial effects of endothelin receptor antagonists on the lung are partially negated by its adverse effects on the heart in pulmonary arterial hypertension.

    • Full Text