Research ArticleAutoimmunity

Long-Term Remissions of Severe Pemphigus After Rituximab Therapy Are Associated with Prolonged Failure of Desmoglein B Cell Response

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Science Translational Medicine  06 Mar 2013:
Vol. 5, Issue 175, pp. 175ra30
DOI: 10.1126/scitranslmed.3005166

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  • The urgent need for randomized clinical trial of rituximab in pemphigus

    This is a long awaited paper by Colliou et al. presenting results of >7-year follow-up study of patients with autoimmune pemphigus treated using rituximab (RTX). Careful examination of the clinical outcome data, however, suggests that the use of RTX does not provide clear advantage over standard treatment, and may even increase the death risk. The most important clinical data of Colliou et al. summarized in Table S1...

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    Competing Interests: None declared.

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