Research ArticleAutoimmunity

Long-Term Remissions of Severe Pemphigus After Rituximab Therapy Are Associated with Prolonged Failure of Desmoglein B Cell Response

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Science Translational Medicine  06 Mar 2013:
Vol. 5, Issue 175, pp. 175ra30
DOI: 10.1126/scitranslmed.3005166

Article Information

vol. 5 no. 175 175ra30

PubMed: 
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History: 
  • Received for publication October 15, 2012
  • Accepted for publication February 4, 2013
  • .

Author Information

  1. Natacha Colliou1,*,
  2. Damien Picard1,*,
  3. Frédérique Caillot1,
  4. Sébastien Calbo1,
  5. Stéphanie Le Corre2,
  6. Annick Lim3,
  7. Brigitte Lemercier3,
  8. Brigitte Le Mauff4,
  9. Maud Maho-Vaillant1,
  10. Serge Jacquot2,
  11. Christophe Bedane5,
  12. Philippe Bernard6,
  13. Frédéric Caux7,
  14. Catherine Prost7,
  15. Emmanuel Delaporte8,
  16. Marie-Sylvie Doutre9,
  17. Brigitte Dreno10,
  18. Nathalie Franck11,
  19. Saskia Ingen-Housz-Oro12,
  20. Olivier Chosidow12,
  21. Christine Pauwels13,
  22. Catherine Picard14,
  23. Jean-Claude Roujeau12,
  24. Michèle Sigal15,
  25. Emmanuelle Tancrede-Bohin16,
  26. Isabelle Templier17,
  27. Rüdiger Eming18,
  28. Michael Hertl18,
  29. Michel D’Incan19,
  30. Pascal Joly1,* and
  31. Philippe Musette1,*,
  1. 1Department of Dermatology, Inserm U905, Institute for Research and Innovation in Biomedicine, Rouen University Hospital, University of Normandy, Rouen 76031, France.
  2. 2Inserm U905, Institute for Research and Innovation in Biomedicine, University of Normandy, Rouen 76031, France.
  3. 3Antiviral Immunity, Biotherapy and Vaccine Unit, Institut Pasteur, Inserm, U668, Paris 75724, France.
  4. 4Department of Immunology and Immunopathology, Caen University Hospital, Caen 14033, France.
  5. 5Department of Dermatology, Limoges University Hospital, Limoges 87042, France.
  6. 6Department of Dermatology, Reims University Hospital, Reims 51092, France.
  7. 7Department of Dermatology, Paris XIII University Hospital, AP-HP, Bobigny 93009, France.
  8. 8Department of Dermatology, Lille University Hospital, Lille 59037, France.
  9. 9Department of Dermatology, Pessac Haut Leveque University Hospital, Bordeaux 33604, France.
  10. 10Department of Dermatology, Nantes University Hospital, Nantes 44093, France.
  11. 11Department of Dermatology, Cochin University Hospital, AP-HP, Paris 75014, France.
  12. 12Department of Dermatology, Henri Mondor University Hospital, AP-HP, Créteil 94000, France.
  13. 13Department of Dermatology, CHI Poissy/Saint-Germain-en-Laye, Saint-Germain-en Laye 78100, France.
  14. 14Department of Dermatology, Bichat University Hospital, AP-HP, Paris 75877, France.
  15. 15Department of Dermatology, Victor Dupouy Hospital, Argenteuil 95107, France.
  16. 16Department of Dermatology, Saint Louis University Hospital, AP-HP, Paris 75010, France.
  17. 17Department of Dermatology, Grenoble University Hospital, Grenoble 38043, France.
  18. 18Faculty of Medicine, Philipp University, Marburg 35037, Germany.
  19. 19Department of Dermatology, Clermont-Ferrand University Hospital, Clermont-Ferrand 63003, France.
  1. To whom correspondence should be addressed. E-mail: philippe.musette{at}chu-rouen.fr
  • * These authors contributed equally to this work.

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