Contents

Contents

• Focus

  • Seeing the Light

    By Adam P. Wojno, Eric A. Pierce, Jean Bennett

    Science Translational Medicine06 Mar 2013 : 175fs8 Full AccessRestricted Access

    One-time gene therapy resulted in multiyear visual improvement, and new approaches were used to evaluate effects on retinal structure.

    • Abstract
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• Commentary

  • Addressing the Growing International Challenge of Cancer: A Multinational Perspective

    By Harold Varmus, Harpal S. Kumar

    Science Translational Medicine06 Mar 2013 : 175cm2 Full AccessRestricted Access

    Leaders of cancer research organizations propose measures to address the growing international challenge of cancer.

    • Abstract
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• Research Articles

  • Carbamylation of Serum Albumin as a Risk Factor for Mortality in Patients with Kidney Failure

    By Anders H. Berg, Christiane Drechsler, Julia Wenger, Roberto Buccafusca, Tammy Hod, Sahir Kalim, Wenda Ramma, Samir M. Parikh, Hanno Steen, David J. Friedman, John Danziger, Christoph Wanner, Ravi Thadhani, S. Ananth Karumanchi

    Science Translational Medicine06 Mar 2013 : 175ra29 Full AccessRestricted Access

    Increased carbamylation of serum albumin is associated with increased mortality in patients with kidney failure.

    • Editor's Summary
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  • Long-Term Remissions of Severe Pemphigus After Rituximab Therapy Are Associated with Prolonged Failure of Desmoglein B Cell Response

    By Natacha Colliou, Damien Picard, Frédérique Caillot, Sébastien Calbo, Stéphanie Le Corre, Annick Lim, Brigitte Lemercier, Brigitte Le Mauff, Maud Maho-Vaillant, Serge Jacquot, Christophe Bedane, Philippe Bernard, Frédéric Caux, Catherine Prost, Emmanuel Delaporte, Marie-Sylvie Doutre, Brigitte Dreno, Nathalie Franck, Saskia Ingen-Housz-Oro, Olivier Chosidow, Christine Pauwels, Catherine Picard, Jean-Claude Roujeau, Michèle Sigal, Emmanuelle Tancrede-Bohin, Isabelle Templier, Rüdiger Eming, Michael Hertl, Michel D’Incan, Pascal Joly, Philippe Musette

    Science Translational Medicine06 Mar 2013 : 175ra30 Full AccessRestricted Access

    Changes in the B cell repertoire mediate long-lasting therapeutic effects of rituximab in pemphigus patients.

    • Editor's Summary
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  • Phenylbutyrate Therapy for Pyruvate Dehydrogenase Complex Deficiency and Lactic Acidosis

    By Rosa Ferriero, Giuseppe Manco, Eleonora Lamantea, Edoardo Nusco, Maria I. Ferrante, Paolo Sordino, Peter W. Stacpoole, Brendan Lee, Massimo Zeviani, Nicola Brunetti-Pierri

    Science Translational Medicine06 Mar 2013 : 175ra31 Full AccessRestricted Access

    Phenylbutyrate enhances pyruvate dehydrogenase enzyme complex (PDHC) activity through inhibition of PDHC kinase, rescues the severe phenotype of a zebrafish model of PDHC deficiency, and prevents systemic lactic acidosis.

    • Editor's Summary
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• Editors' Choice

  • Dead or Alive? Nanopatrols Report

    By Natalie Artzi

    Science Translational Medicine06 Mar 2013 : 175ec38 Full AccessRestricted Access

    New nanosensor-based imaging platform reports on transplanted cell viability.

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  • Mast Cells Help Bacteria Hang Out After the Party

    By Christopher R. Polage

    Science Translational Medicine06 Mar 2013 : 175ec39 Full AccessRestricted Access

    Mast cell-derived IL-10 shifts the bladder towards immune tolerance and limits adaptive immunity to pathogens.

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  • Energy Hunting(tin)

    By Anne Schaefer

    Science Translational Medicine06 Mar 2013 : 175ec40 Full AccessRestricted Access

    Vesicles move down neuronal axons powered by local glycolysis, a process that requires huntingtin, the protein defective in Huntington’s disease.

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  • Imaging the Beating Heart

    By David A. Zidar

    Science Translational Medicine06 Mar 2013 : 175ec41 Full AccessRestricted Access

    Intravital microscopy of mouse hearts reveals rapid immune cell influx after a heart attack.

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