Contents
Vol 5, Issue 175
Contents
Focus
- Seeing the Light
One-time gene therapy resulted in multiyear visual improvement, and new approaches were used to evaluate effects on retinal structure.
Commentary
- Addressing the Growing International Challenge of Cancer: A Multinational Perspective
Leaders of cancer research organizations propose measures to address the growing international challenge of cancer.
Research Articles
- Carbamylation of Serum Albumin as a Risk Factor for Mortality in Patients with Kidney Failure
Increased carbamylation of serum albumin is associated with increased mortality in patients with kidney failure.
- Long-Term Remissions of Severe Pemphigus After Rituximab Therapy Are Associated with Prolonged Failure of Desmoglein B Cell Response
Changes in the B cell repertoire mediate long-lasting therapeutic effects of rituximab in pemphigus patients.
- Phenylbutyrate Therapy for Pyruvate Dehydrogenase Complex Deficiency and Lactic Acidosis
Phenylbutyrate enhances pyruvate dehydrogenase enzyme complex (PDHC) activity through inhibition of PDHC kinase, rescues the severe phenotype of a zebrafish model of PDHC deficiency, and prevents systemic lactic acidosis.
Editors' Choice
- Dead or Alive? Nanopatrols Report
New nanosensor-based imaging platform reports on transplanted cell viability.
- Mast Cells Help Bacteria Hang Out After the Party
Mast cell-derived IL-10 shifts the bladder towards immune tolerance and limits adaptive immunity to pathogens.
- Energy Hunting(tin)
Vesicles move down neuronal axons powered by local glycolysis, a process that requires huntingtin, the protein defective in Huntington’s disease.
- Imaging the Beating Heart
Intravital microscopy of mouse hearts reveals rapid immune cell influx after a heart attack.
