Contents
Vol 5, Issue 174
Editorial
- No Time to Waste
The United States must strengthen its support of the medical research and development ecosystem.
Focus
- A New Horizon in Asthma: Inhibiting ILC Function
Innate lymphoid cells (ILCs) produce cytokines that drive allergic responses in asthma and can be inhibited by lipoxin A4 (Barnig et al., this issue).
Research Articles
- Lipoxin A4 Regulates Natural Killer Cell and Type 2 Innate Lymphoid Cell Activation in Asthma
The pro-resolving mediator lipoxin A4 regulates natural killer cells and type 2 innate lymphoid cells in severe asthma.
- Transferred WT1-Reactive CD8+ T Cells Can Mediate Antileukemic Activity and Persist in Post-Transplant Patients
Donor-derived WT1-specific CD8+ T cells transferred after hematopoietic cell transplantation mediate antileukemic activity and can establish persistent responses without toxicity to normal tissues in high-risk leukemia patients.
- Mutant HSP70 Reverses Autoimmune Depigmentation in Vitiligo
Vitiligo can be reversed through immune targeting with mutant heat shock protein 70.
Editors' Choice
- The Plasma Cell Fountain of Youth?
Plasma cell longevity requires the antiapoptotic molecule Mcl-1.
- The Buzz in Chronic Wound Treatment
Honey can be used as an antimicrobial to treat common bacteria in chronic skin wound infections.
- Insights into Aging Vessels
The transcription factor JunD links oxidative stress and vascular aging.