27 February 2013
Vol 5, Issue 174

About The Cover

Cover image expansion

ONLINE COVER Lipoxin Doubles Up. Despite its many triggers—exercise, animals, cold air—the underlying causes of inflammation in asthma are still unknown. In this week’s issue, Barnig et al. found that type 2 innate lymphoid cells (ILC2s) promoted lung inflammation and natural killer (NK) cells induced eosinophil apoptosis in asthmatic patients. Addition of the drug lipoxin A4 (shown on the cover in a space-filling model) resolved the proinflammatory activities of both ILC2s and NK cells, giving new treatments for asthma a breath of fresh air. See related Focus by Peebles. [CREDIT: C. BICKEL/SCIENCE TRANSLATIONAL MEDICINE]