Contents
Vol 5, Issue 172
Contents
Focus
- Vaccination Route Matters for Mucosal Tumors
Immunization route may be pivotal for tissue-specific localization of the effector T cell response (Sandoval et al., this issue).
- Ovarian Aging: Breaking Up Is Hard to Fix
Double-stranded breaks (DSBs) in DNA—which are essential for normal development—accumulate with age and contribute to reproductive aging. Age-related inhibition of DSB repair diminishes ovarian reserve in mice and women.
Research Articles
- Mucosal Imprinting of Vaccine-Induced CD8+ T Cells Is Crucial to Inhibit the Growth of Mucosal Tumors
Mucosal vaccination induces targeted CD8+ T cell homing to inhibit mucosal tumors.
- Impairment of BRCA1-Related DNA Double-Strand Break Repair Leads to Ovarian Aging in Mice and Humans
DNA double-strand break repair has a central role in oocyte aging.
- Melamine-Induced Renal Toxicity Is Mediated by the Gut Microbiota
Melamine is converted to cyanuric acid by the gut microbe Klebsiella, leading to melamine-cyanurate-urate coprecipitation that is associated with nephrotoxicity.
Editors' Choice
- TRIPpin’ on a Fat Cell
A newly discovered role for the transcription coregulator TRIP-Br2 may provide a target for preventing and treating obesity.
- The Early Bird Gets the Virus
HIV-positive persons treated soon after infection have a greater chance of retaining functional immune cells.
- Running Interference on Tumor Growth
A new clinical trial using siRNA to treat patients with liver tumors demonstrates safety and early signs of efficacy.
- You Want To Give Me WHAT?
Administration of feces proves superior to antibiotics for treatment of a common and frequently fatal bowel infection.
- Revisiting Metformin
Biguanides suppress hepatic glucagon signaling by decreasing production of cyclic AMP.
