Research ArticleNon–small cell lung cancer

Blocking NRG1 and Other Ligand-Mediated Her4 Signaling Enhances the Magnitude and Duration of the Chemotherapeutic Response of Non–Small Cell Lung Cancer

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Science Translational Medicine  06 Feb 2013:
Vol. 5, Issue 171, pp. 171ra18
DOI: 10.1126/scitranslmed.3004438

Article Information

vol. 5 no. 171 171ra18

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication June 6, 2012
  • Accepted for publication December 7, 2012
  • .

Author Information

  1. Ganapati V. Hegde1,*,
  2. Cecile C. de la Cruz1,*,
  3. Cecilia Chiu2,
  4. Navneet Alag1,
  5. Gabriele Schaefer3,
  6. Lisa Crocker4,
  7. Sarajane Ross4,
  8. David Goldenberg4,
  9. Mark Merchant4,
  10. Janet Tien4,
  11. Lily Shao3,
  12. Leslie Roth5,
  13. Siao-Ping Tsai5,
  14. Scott Stawicki2,
  15. Zhaoyu Jin2,
  16. Shelby K. Wyatt6,
  17. Richard A. D. Carano6,
  18. Yanyan Zheng7,
  19. E. Alejandro Sweet-Cordero7,
  20. Yan Wu2 and
  21. Erica L. Jackson1,
  1. 1Department of Discovery Oncology, Genentech Inc., South San Francisco, CA 94080, USA.
  2. 2Department of Antibody Engineering, Genentech Inc., South San Francisco, CA 94080, USA.
  3. 3Department of Research Oncology, Genentech Inc., South San Francisco, CA 94080, USA.
  4. 4Department of Translational Oncology, Genentech Inc., South San Francisco, CA 94080, USA.
  5. 5Department of Biochemical and Cellular Pharmacology, Genentech Inc., South San Francisco, CA 94080, USA.
  6. 6Department of Biomedical Imaging, Genentech Inc., South San Francisco, CA 94080, USA.
  7. 7Cancer Biology Program, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA.
  1. To whom correspondence should be addressed. E-mail: ericaj{at}gene.com
  • * These authors contributed equally to this work.

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