TSLP Elicits IL-33–Independent Innate Lymphoid Cell Responses to Promote Skin Inflammation

Brian S. Kim; Mark C. Siracusa; Steven A. Saenz; Mario Noti; Laurel A. Monticelli; Gregory F. Sonnenberg; Matthew R. Hepworth; Abby S. Van Voorhees; Michael R. Comeau; David Artis

doi:10.1126/scitranslmed.3005374

Research ArticleImmunology

TSLP Elicits IL-33–Independent Innate Lymphoid Cell Responses to Promote Skin Inflammation

Brian S. Kim¹,²,³,
Mark C. Siracusa¹,²,
Steven A. Saenz¹,²,
Mario Noti¹,²,
Laurel A. Monticelli¹,²,
Gregory F. Sonnenberg¹,²,
Matthew R. Hepworth¹,²,
Abby S. Van Voorhees³,
Michael R. Comeau⁴ and
David Artis¹,²,⁵,*

¹Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
²Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
³Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
⁴Inflammation Research, Amgen Inc., Seattle, WA 98119, USA.
⁵Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

↵*To whom correspondence should be addressed. E-mail: dartis{at}mail.med.upenn.edu

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Science Translational Medicine 30 Jan 2013:
Vol. 5, Issue 170, pp. 170ra16
DOI: 10.1126/scitranslmed.3005374

Brian S. Kim

1Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

2Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

3Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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Mark C. Siracusa

1Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

2Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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Steven A. Saenz

1Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

2Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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Mario Noti

1Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

2Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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Laurel A. Monticelli

1Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

2Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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Gregory F. Sonnenberg

1Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

2Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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Matthew R. Hepworth

1Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

2Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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Abby S. Van Voorhees

3Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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Michael R. Comeau

4Inflammation Research, Amgen Inc., Seattle, WA 98119, USA.

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David Artis

1Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

2Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

5Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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For correspondence: dartis@mail.med.upenn.edu

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TSLP Elicits IL-33–Independent Innate Lymphoid Cell Responses to Promote Skin Inflammation

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