TSLP Elicits IL-33–Independent Innate Lymphoid Cell Responses to Promote Skin Inflammation

Brian S. Kim; Mark C. Siracusa; Steven A. Saenz; Mario Noti; Laurel A. Monticelli; Gregory F. Sonnenberg; Matthew R. Hepworth; Abby S. Van Voorhees; Michael R. Comeau; David Artis

doi:10.1126/scitranslmed.3005374

Research ArticleImmunology

TSLP Elicits IL-33–Independent Innate Lymphoid Cell Responses to Promote Skin Inflammation

Brian S. Kim¹,²,³,
Mark C. Siracusa¹,²,
Steven A. Saenz¹,²,
Mario Noti¹,²,
Laurel A. Monticelli¹,²,
Gregory F. Sonnenberg¹,²,
Matthew R. Hepworth¹,²,
Abby S. Van Voorhees³,
Michael R. Comeau⁴ and
David Artis¹,²,⁵,*

¹Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
²Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
³Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
⁴Inflammation Research, Amgen Inc., Seattle, WA 98119, USA.
⁵Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

↵*To whom correspondence should be addressed. E-mail: dartis{at}mail.med.upenn.edu

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Science Translational Medicine 30 Jan 2013:
Vol. 5, Issue 170, pp. 170ra16
DOI: 10.1126/scitranslmed.3005374

Brian S. Kim

Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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Mark C. Siracusa

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Steven A. Saenz

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Mario Noti

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Laurel A. Monticelli

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Gregory F. Sonnenberg

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Matthew R. Hepworth

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Abby S. Van Voorhees

Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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Michael R. Comeau

Inflammation Research, Amgen Inc., Seattle, WA 98119, USA.

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David Artis

Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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For correspondence: dartis@mail.med.upenn.edu

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TSLP Elicits IL-33–Independent Innate Lymphoid Cell Responses to Promote Skin Inflammation

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