Contents
Vol 5, Issue 170
Contents
Focus
- Insulin Resistance from Binge Drinking: It’s All in Your Head
Binge alcohol exposure impairs hepatic insulin action by blunting insulin receptor signaling in the brain (Lindtner et al., this issue).
Research Articles
- CD271+ Bone Marrow Mesenchymal Stem Cells May Provide a Niche for Dormant Mycobacterium tuberculosis
CD271+ bone marrow stem cells may provide a protective intracellular niche for dormant Mycobacterium tuberculosis.
- Binge Drinking Induces Whole-Body Insulin Resistance by Impairing Hypothalamic Insulin Action
Rats given alcohol to simulate binge drinking exhibit the first signs of diabetes, a result of altered insulin action in the brain.
- In Active Relapsing-Remitting Multiple Sclerosis, Effector T Cell Resistance to Adaptive Tregs Involves IL-6–Mediated Signaling
Effector T cells in patients with active RRMS can be resistant to immune tolerance through a mechanism involving IL-6R signaling.
- TSLP Elicits IL-33–Independent Innate Lymphoid Cell Responses to Promote Skin Inflammation
Group 2 innate lymphoid cells are essential to the pathogenesis of atopic dermatitis–like disease in a TSLP-dependent, IL-33–independent manner.
Editors' Choice
- Success May Require Being Direct
Injection of tuberculosis vaccine directly into the lymph nodes is more effective than subcutaneous vaccination.
- Catching a Glimpse of Gut Bacteria–Drug Interactions
Antibiotics and other drugs affect gene expression in gut bacterial communities.
- MID1 Mediates Acute Asthma Exacerbations
A possible new drug target activates asthma through the innate immune pathway.
