Research ArticleCancer

DNA Methylation Alterations Exhibit Intraindividual Stability and Interindividual Heterogeneity in Prostate Cancer Metastases

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Science Translational Medicine  23 Jan 2013:
Vol. 5, Issue 169, pp. 169ra10
DOI: 10.1126/scitranslmed.3005211

Article Information

vol. 5 no. 169 169ra10

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication October 23, 2012
  • Accepted for publication January 7, 2013
  • .

Author Information

  1. Martin J. Aryee1,2,*,
  2. Wennuan Liu3,
  3. Julia C. Engelmann1,,
  4. Philipp Nuhn1,
  5. Meltem Gurel1,
  6. Michael C. Haffner1,
  7. David Esopi1,
  8. Rafael A. Irizarry4,
  9. Robert H. Getzenberg1,5,,
  10. William G. Nelson1,5,
  11. Jun Luo1,5,
  12. Jianfeng Xu3,
  13. William B. Isaacs1,5,
  14. G. Steven Bova6,§ and
  15. Srinivasan Yegnasubramanian1,7,
  1. 1Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD 21231, USA.
  2. 2Oncology Department, Division of Biostatistics, Johns Hopkins University, Baltimore, MD 21231, USA.
  3. 3Center for Cancer Genomics, Center for Genomics and Personalized Medicine Research, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.
  4. 4Biostatistics Department, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA.
  5. 5Brady Urological Institute, Johns Hopkins University, Baltimore, MD 21287, USA.
  6. 6Pathology Department, Johns Hopkins University, Baltimore, MD 21287, USA.
  7. 7Johns Hopkins Physical Sciences in Oncology Center, Johns Hopkins University, Baltimore, MD 21231, USA.
  1. To whom correspondence should be addressed. E-mail: syegnasu{at}jhmi.edu
  • * Present address: Department of Pathology, Massachusetts General Hospital, Charlestown, MA 02129, USA.

  • Present address: University of Regensburg, Regensburg, Germany.

  • Present address: GTx Inc., Memphis, TN 38103, USA.

  • § Present address: Institute of Biomedical Technology, PELICAN-Personalized Cancer Medicine Group, University of Tampere, Biokatu 8, FI-33014 Tampere, Finland.

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