Contents
Vol 5, Issue 169
Contents
Editorial
- Culture of Impact: Faculty as Mentors for Student Entrepreneurs
Students are the entrepreneurs on campus and need experienced faculty mentors.
Focus
- A Splicing Twist on Metastasis
An oncogenic splice variant of the transcription factor KLF6 is associated with metastasis and poor survival in node-negative breast cancer.
Research Articles
- DNA Methylation Alterations Exhibit Intraindividual Stability and Interindividual Heterogeneity in Prostate Cancer Metastases
Prostate tumors develop a unique epigenetic DNA methylation signature that is clonally maintained in disseminated metastases.
- Pancreatic Digestive Enzyme Blockade in the Intestine Increases Survival After Experimental Shock
Blockade of pancreatic digestive enzymes in the intestine ameliorates shock and multiorgan failure and improves survival in rodents.
- KLF6-SV1 Drives Breast Cancer Metastasis and Is Associated with Poor Survival
The KLF6-SV1 splice variant is associated with poor prognosis in early-stage human breast cancer and drives metastasis through the regulation of an EMT-like program in culture and in vivo.
Editors' Choice
- Pulmonary Hypertension’s Appealing News
The apelin peptide regulates the fibroblast growth factor signaling in the pulmonary vasculature.
- We Got the Beat
The changing emotional expressions generated by music are universal and parallel those generated by movement.
- The Trojan Horse for Hematologic Malignancies
siRNAs targeting STAT3 decrease survival of tumor cells and activate the host immune system.
- Fishing for Allergic Antibodies
Dermal mast cells reach into the circulation to acquire IgE in allergic anaphylaxis.
