23 January 2013
Vol 5, Issue 169

About The Cover

Cover image expansion

ONLINE COVER A Splice of the Cancer Pie. Shown is a cross section of the heterogeneous breast tumor microenvironment. Hatami et al. show that KLF6-SV1, an alternative splice variant of the tumor suppressor Krüppel-like factor 6, drives epithelial-mesenchymal transition through increased expression of the transcription factor TWIST1, transforming noninvasive tumor cells (pink) into highly metastatic tumor cells (red). Also shown are extracellular matrix (brown), fibroblasts (green), and infiltrating immune cells (blue). See also the accompanying Focus by Olson and Joyce. [CREDIT: Y. HAMMOND/SCIENCE TRANSLATIONAL MEDICINE]