State of the Art ReviewFibrosis

Therapy for Fibrotic Diseases: Nearing the Starting Line

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Science Translational Medicine  09 Jan 2013:
Vol. 5, Issue 167, pp. 167sr1
DOI: 10.1126/scitranslmed.3004700

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Editor's Summary

Fibrosis, the accumulation of excess extracellular matrix in injured tissue, is the final common pathway for numerous diseases, including many of the lung, liver, kidney, and skin. This State of the Art Review outlines an emerging consensus that these diseases have many underlying features in common. The authors further describe ongoing efforts to develop effective therapies, including a discussion of obstacles to progress.

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