Evaluation of DNA from the Papanicolaou Test to Detect Ovarian and Endometrial Cancers

Isaac Kinde; Chetan Bettegowda; Yuxuan Wang; Jian Wu; Nishant Agrawal; Ie-Ming Shih; Robert Kurman; Fanny Dao; Douglas A. Levine; Robert Giuntoli; Richard Roden; James R. Eshleman; Jesus Paula Carvalho; Suely Kazue Nagahashi Marie; Nickolas Papadopoulos; Kenneth W. Kinzler; Bert Vogelstein; Luis A. Diaz

doi:10.1126/scitranslmed.3004952

Research ArticleOvarian Cancer

Evaluation of DNA from the Papanicolaou Test to Detect Ovarian and Endometrial Cancers

Isaac Kinde¹,*,
Chetan Bettegowda¹,²,*,
Yuxuan Wang¹,*,
Jian Wu¹,³,
Nishant Agrawal¹,⁴,
Ie-Ming Shih⁵,
Robert Kurman⁵,
Fanny Dao⁶,
Douglas A. Levine⁶,
Robert Giuntoli⁷,
Richard Roden⁵,
James R. Eshleman⁵,
Jesus Paula Carvalho⁸,
Suely Kazue Nagahashi Marie⁸,⁹,
Nickolas Papadopoulos¹,
Kenneth W. Kinzler¹,
Bert Vogelstein¹,† and
Luis A. Diaz Jr.¹,†

¹The Ludwig Center for Cancer Genetics and Therapeutics, The Swim Across America Laboratory at Johns Hopkins, and The Howard Hughes Medical Institute at Johns Hopkins Kimmel Cancer Center, Baltimore, MD 21287, USA.
²Department of Neurosurgery, The Johns Hopkins Medical Institutes, Baltimore, MD 21231, USA.
³MyGenostics Inc., 801 West Baltimore Street, Suite 502L, Baltimore, MD 21201, USA.
⁴Department of Otolaryngology–Head and Neck Surgery, The Johns Hopkins Medical Institutes, Baltimore, MD 21231, USA.
⁵Department of Pathology, The Johns Hopkins Medical Institutes, Baltimore, MD 21231, USA.
⁶Gynecology Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.
⁷Department of Gynecology and Obstetrics, The Johns Hopkins Medical Institutes, Baltimore, MD 21231, USA.
⁸Institute of Cancer of Sao Paulo State, School of Medicine, University of Sao Paulo, Sao Paulo 01246903, Brazil.
⁹Departments of Pathology and Neurology, School of Medicine, University of Sao Paulo, Sao Paulo 01246903, Brazil.

↵†To whom correspondence should be addressed. E-mail: bertvog{at}gmail.com (B.V.); ldiaz1{at}jhmi.edu (L.A.D.)

↵* These authors contributed equally to this work.

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Science Translational Medicine 09 Jan 2013:
Vol. 5, Issue 167, pp. 167ra4
DOI: 10.1126/scitranslmed.3004952

Isaac Kinde

1The Ludwig Center for Cancer Genetics and Therapeutics, The Swim Across America Laboratory at Johns Hopkins, and The Howard Hughes Medical Institute at Johns Hopkins Kimmel Cancer Center, Baltimore, MD 21287, USA.

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Chetan Bettegowda

2Department of Neurosurgery, The Johns Hopkins Medical Institutes, Baltimore, MD 21231, USA.

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Yuxuan Wang

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Jian Wu

3MyGenostics Inc., 801 West Baltimore Street, Suite 502L, Baltimore, MD 21201, USA.

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Nishant Agrawal

4Department of Otolaryngology–Head and Neck Surgery, The Johns Hopkins Medical Institutes, Baltimore, MD 21231, USA.

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Ie-Ming Shih

5Department of Pathology, The Johns Hopkins Medical Institutes, Baltimore, MD 21231, USA.

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Robert Kurman

5Department of Pathology, The Johns Hopkins Medical Institutes, Baltimore, MD 21231, USA.

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Fanny Dao

6Gynecology Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

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Douglas A. Levine

6Gynecology Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

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Robert Giuntoli

7Department of Gynecology and Obstetrics, The Johns Hopkins Medical Institutes, Baltimore, MD 21231, USA.

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Richard Roden

5Department of Pathology, The Johns Hopkins Medical Institutes, Baltimore, MD 21231, USA.

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James R. Eshleman

5Department of Pathology, The Johns Hopkins Medical Institutes, Baltimore, MD 21231, USA.

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Jesus Paula Carvalho

8Institute of Cancer of Sao Paulo State, School of Medicine, University of Sao Paulo, Sao Paulo 01246903, Brazil.

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Suely Kazue Nagahashi Marie

8Institute of Cancer of Sao Paulo State, School of Medicine, University of Sao Paulo, Sao Paulo 01246903, Brazil.

9Departments of Pathology and Neurology, School of Medicine, University of Sao Paulo, Sao Paulo 01246903, Brazil.

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Nickolas Papadopoulos

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Kenneth W. Kinzler

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Bert Vogelstein

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For correspondence: bertvog@gmail.com ldiaz1@jhmi.edu

Luis A. Diaz Jr.

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For correspondence: bertvog@gmail.com ldiaz1@jhmi.edu

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Evaluation of DNA from the Papanicolaou Test to Detect Ovarian and Endometrial Cancers

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