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Familial Hypercholesterolemia and Atherosclerosis in Cloned Minipigs Created by DNA Transposition of a Human PCSK9 Gain-of-Function Mutant

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Science Translational Medicine  02 Jan 2013:
Vol. 5, Issue 166, pp. 166ra1
DOI: 10.1126/scitranslmed.3004853

Article Information

vol. 5 no. 166 166ra1

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication August 27, 2012
  • Accepted for publication November 28, 2012
  • .

Author Information

  1. Rozh H. Al-Mashhadi1,
  2. Charlotte B. Sørensen2,
  3. Peter M. Kragh3,
  4. Christina Christoffersen4,
  5. Martin B. Mortensen1,
  6. Lars P. Tolbod5,
  7. Troels Thim1,
  8. Yutao Du3,
  9. Juan Li3,*,
  10. Ying Liu3,
  11. Brian Moldt2,
  12. Mette Schmidt6,
  13. Gabor Vajta3,7,
  14. Torben Larsen3,
  15. Stig Purup3,
  16. Lars Bolund2,8,
  17. Lars B. Nielsen4,9,
  18. Henrik Callesen3,
  19. Erling Falk1,
  20. Jacob Giehm Mikkelsen2 and
  21. Jacob F. Bentzon1,
  1. 1Department of Cardiology, Aarhus University Hospital, and Department of Clinical Medicine, Aarhus University, Brendstrupgaardsvej 100, DK-8200 Aarhus N, Denmark.
  2. 2Department of Biomedicine, Aarhus University, Wilhelm Meyers Allé 3, Building 1230, DK-8000 Aarhus C, Denmark.
  3. 3Department of Animal Science, Aarhus University, Blichers Allé 20, DK-8830 Tjele, Denmark.
  4. 4Department of Clinical Biochemistry, Rigshospitalet, Blegdamsvej 9, DK-2100 Copenhagen, Denmark.
  5. 5Department of Nuclear Medicine and PET-Centre, Aarhus University Hospital, DK-8200 Aarhus N, Denmark.
  6. 6Department of Large Animal Sciences, University of Copenhagen, Dyrlægevej 68, DK-1870 Frederiksberg C, Denmark.
  7. 7Central Queensland University, Bruce Highway, Rockhampton, Queensland 4702, Australia.
  8. 8BGI (HuaDa JiYin), BGI-Shenzhen, Beishan Industrial Zone, Yantian District, Shenzhen 518083, China.
  9. 9Department of Biomedical Sciences, University of Copenhagen, Blegdamsvej 3, 2200 Copenhagen N, Denmark.
  1. To whom correspondence should be addressed. E-mail: jben{at}ki.au.dk
  • * Present address: Animal Science and Technology, Nanjing Agricultural University, Nanjing Weigang No.1, 210095 Nanjing, China.

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