Contents
Vol 5, Issue 166
Contents
Focus
- Mighty Minipig in Fight Against Cardiovascular Disease
A cloned transgenic minipig model of hypercholesterolemia and accelerated atherosclerosis could accelerate discovery of new therapies for atherosclerotic cardiovascular disease.
Research Articles
- Familial Hypercholesterolemia and Atherosclerosis in Cloned Minipigs Created by DNA Transposition of a Human PCSK9 Gain-of-Function Mutant
A transgenic pig model of familial hypercholesterolemia can be used for translational atherosclerosis research.
- A Dendritic Cell–Based Vaccine Elicits T Cell Responses Associated with Control of HIV-1 Replication
Therapeutic DC vaccines elicit HIV-1–specific immune responses that change viral set point in patients of cART.
- Pazopanib Enhances Paclitaxel-Induced Mitotic Catastrophe in Anaplastic Thyroid Cancer
Pazopanib and paclitaxel produce cytotoxic synergy in thyroid cancer models through inhibition of aurora kinase A.
Editors' Choice
- Maintaining the T Cell Status Quo
Under lymphopenic conditions, T cells work hard to maintain static peripheral numbers.
- Solving Pathogen Sudoku
A new screen dissects complex interactions between pathogen and host to pinpoint factors responsible for virulence.
- Bioinspired Glue for Healing Atherosclerotic Plaques
Adhesives inspired by marine animals may protect against atherosclerosis.
- Statins Beyond Heart Disease: A New Treatment for the Sepsis Syndrome?
Statin treatment may prevent the progression of sepsis and onset of organ failure.