Contents

Contents

• Focus

  • Mighty Minipig in Fight Against Cardiovascular Disease

    By Anandita Agarwala, Jeffrey Billheimer, Daniel J. Rader

    Science Translational Medicine02 Jan 2013 : 166fs1 Full AccessRestricted Access

    A cloned transgenic minipig model of hypercholesterolemia and accelerated atherosclerosis could accelerate discovery of new therapies for atherosclerotic cardiovascular disease.

    • Abstract
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• Research Articles

  • Familial Hypercholesterolemia and Atherosclerosis in Cloned Minipigs Created by DNA Transposition of a Human PCSK9 Gain-of-Function Mutant

    By Rozh H. Al-Mashhadi, Charlotte B. Sørensen, Peter M. Kragh, Christina Christoffersen, Martin B. Mortensen, Lars P. Tolbod, Troels Thim, Yutao Du, Juan Li, Ying Liu, Brian Moldt, Mette Schmidt, Gabor Vajta, Torben Larsen, Stig Purup, Lars Bolund, Lars B. Nielsen, Henrik Callesen, Erling Falk, Jacob Giehm Mikkelsen, Jacob F. Bentzon

    Science Translational Medicine02 Jan 2013 : 166ra1 Full AccessRestricted Access

    A transgenic pig model of familial hypercholesterolemia can be used for translational atherosclerosis research.

    • Editor's Summary
    • Abstract
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  • A Dendritic Cell–Based Vaccine Elicits T Cell Responses Associated with Control of HIV-1 Replication

    By Felipe García, Nuria Climent, Alberto C. Guardo, Cristina Gil, Agathe León, Brigitte Autran, Jeffrey D. Lifson, Javier Martínez-Picado, Judit Dalmau, Bonaventura Clotet, Josep M. Gatell, Montserrat Plana, Teresa Gallart, For the DCV2/MANON07-ORVACS Study Group

    Science Translational Medicine02 Jan 2013 : 166ra2 Full AccessRestricted Access

    Therapeutic DC vaccines elicit HIV-1–specific immune responses that change viral set point in patients of cART.

    • Editor's Summary
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  • Pazopanib Enhances Paclitaxel-Induced Mitotic Catastrophe in Anaplastic Thyroid Cancer

    By Crescent R. Isham, Ayoko R. Bossou, Vivian Negron, Kelly E. Fisher, Rakesh Kumar, Laura Marlow, Wilma L. Lingle, Robert C. Smallridge, Eric J. Sherman, Vera J. Suman, John A. Copland, Keith C. Bible

    Science Translational Medicine02 Jan 2013 : 166ra3 Full AccessRestricted Access

    Pazopanib and paclitaxel produce cytotoxic synergy in thyroid cancer models through inhibition of aurora kinase A.

    • Editor's Summary
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• Editors' Choice

  • Maintaining the T Cell Status Quo

    By Jagdeep S. Obhrai

    Science Translational Medicine02 Jan 2013 : 166ec1 Full AccessRestricted Access

    Under lymphopenic conditions, T cells work hard to maintain static peripheral numbers.

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  • Solving Pathogen Sudoku

    By Joshua D. Shrout

    Science Translational Medicine02 Jan 2013 : 166ec2 Full AccessRestricted Access

    A new screen dissects complex interactions between pathogen and host to pinpoint factors responsible for virulence.

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  • Bioinspired Glue for Healing Atherosclerotic Plaques

    By Carsten Skarke

    Science Translational Medicine02 Jan 2013 : 166ec3 Full AccessRestricted Access

    Adhesives inspired by marine animals may protect against atherosclerosis.

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  • Statins Beyond Heart Disease: A New Treatment for the Sepsis Syndrome?

    By Amir A. Zeki

    Science Translational Medicine02 Jan 2013 : 166ec4 Full AccessRestricted Access

    Statin treatment may prevent the progression of sepsis and onset of organ failure.

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