02 January 2013
Vol 5, Issue 166

About The Cover

Cover image expansion

ONLINE COVER A Mighty Minipig. Healthy pigs can develop atherosclerosis similar to humans when fed a high-fat, high-cholesterol diet. However, this does not mimic the genetic form of the disease, familial hypercholesterolemia (FH), where people on normal diets still suffer from high levels of "bad" cholesterol and ultimately develop atherosclerosis. In this issue, Al-Mashhadi and colleagues created a large animal model of FH by genetically altering Yucatan minipigs (on cover). These animals reproduce features of the human disease, and could thus be used for translational atherosclerosis research into new drugs and imaging agents. See related Focus by Agarwala et al. [CREDIT: J. RAIS/AARHUS UNIVERSITY]