Contents
Vol 4, Issue 165
Contents
Commentary
- To Share or Not To Share: That Is Not the Question
Sharing clinical and biomedical data could accelerate translational research.
Research Articles
- Genetic Correction of Human Induced Pluripotent Stem Cells from Patients with Spinal Muscular Atrophy
Motor neurons generated from genetically corrected iPSCs derived from patients with spinal muscular atrophy show rescue of the disease phenotype.
- Long-Term Follow-Up After Gene Therapy for Canavan Disease
Gene therapy for Canavan disease results in a decrease in pathologically elevated N-acetyl-aspartate concentrations in the brain and long-term clinical stabilization.
- Multimodal Actions of Neural Stem Cells in a Mouse Model of ALS: A Meta-Analysis
A meta-analysis reports the beneficial effects of transplanting mouse or human neural stem cells into the spinal cord of the SOD1G93A mouse, a model of ALS.
Review
- Hidden Killers: Human Fungal Infections
The lack of robust rapid diagnostic tests, safe and effective drugs, and preventative vaccines hampers treatment of patients with invasive fungal infections.
Editors' Choice
- Uncovering the Unseen
Single-cell analysis in three-dimensional tissue samples is enabled by light sheet fluorescence microscopy.
- Stress Structures the Brain
Stress experienced as an infant can alter blood cortisol concentrations and brain development, leading to emotion dysregulation in adolescence.
- The Teratoma Factory
iPSC-generated teratomas can be sources of hematopoietic stem cells, antibodies, and cytokines.
- “Heads,” Flesh-Eating Disease; “Tails,” Just a Sore Throat
Antibody binding orientation changes between severe streptococcal infection and benign colonization.
- Social Media Meet Multiple Sclerosis
Connections cultivated through an online community of scientists may accelerate multiple sclerosis research.
Errata
